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Chemical structure of agelasimine A

Agelasimines are a group of adenine-related bicyclic diterpenoids isolated from the orange sponge Agelas mauritania. Their chemical structures are closely related to the agelasines.

Both groups of compounds display a range of biological activities, such as cytotoxicity, inhibition of adenosine transfer into rabbit erythrocytes (red blood cells), Ca2+ channel antagonistic action, α1 adrenergic blockade and others.

Both compounds have been reproduced in the laboratory by organic synthesis.


  • Fathi-Afshar R, Allen TM, Krueger CA; et al. (April 1989). "Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana". Can. J. Physiol. Pharmacol. 67 (4): 276–81. doi:10.1139/y89-045. PMID 2758370. 
  • Fathi-Afshar, R.; Allen, T. M., Canadian Journal of Chemistry, 1988, 66(1), 45-50.
  • Ohba, Masashi; Iizuka, Kazuaki; Ishibashi, Hiroyuki; Fujii, Tozo., Tetrahedron 1997, 53(50), 16977-16986.