A son of an Egyptian mother and an Algerian father who then left his mum and Mekky's brothers at young age. Mekky was raised as a kid in a place called El Talbia of El Haram, Egypt. He began his career in the after graduating from the directing division at Cairo Higher Institute of Cinema. Mekky started out directing several short films such as Yabanee Asly (An Original Japanese) before directing El Hassa El Sab'a (The Seventh Sense), which starred Ahmed El-Fishawy, in 2005. That work was adapted from a short film that Mekky had previously directed in 2003. Mekky has collaborated with his sister Inas Mekky in directing several television productions, including Lahazat Hariga (Crucial Moments) and Tamer wa Shaweiyah (Tamer and Shaweiyah) in which he also played the role of Haitham Dabour.
Mekky stars in the Ramadan Egyptian comedy series El Kabeer Awy in which he plays both main characters, two brothers vying for the inheritance of their deceased father. In 2013, the third season of El Kebir Awi introduces a third brother, also played by Mekky. Besides his career in cinema, Mekky has also continued to write rap songs that he performs in films or uploads to the internet.