Alfredo Pavlovsky

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Alfredo Pavlovsky (24 November 1907 – 26 April 1984) was an Argentinian physician, notable for having discovered that haemophilia has two types (A and B).[1][2]

Life and career[edit]

Born to a Russian immigrant and a mother from Mendoza Province, Pavlovsky graduated in medicine in 1931. He worked as Bernardo Houssay's assistant professor in phisiology.[1] In 1936 Pavlovsky established in Boston and started working with Drs. George Minot and William P. Murphy, both Nobel Prize laureates. During that stay, Pavlovsky met William Dameshek, the founder of the American Society of Hematology.[1] Back in his country, Pavlovsky founded the Haemophilia Foundation (Fundación de la Hemofilia)[3] in 1944 and the Foundation to Combat Leukemia (Fundación para Combatir la Leucemia) (FUNDALEU) in 1956, with the purpose to advance etiologic research and treatment of these diseases. He was the co-founder of the International Society of Hematology.[1] In 1955, Pavlovsky was appointed Director of the newly established Medicine Nacional Academy's Hematologic Research Institute (Instituto de Investigaciones Hematológicas de la Academia Nacional de Medicina). He died in 1984, with 5 children and 19 grandchildren.[1]

Achievments[edit]

In 1944, Pavlovsky mixed the plasmas from two different patients with haemophilia and obtained mutual correction of the defect.[4] He later discovered that haemophilia can be split in two types.[1] The different factor deficiencies would be distinguished in the 1950s and 1960s.[2] In 1947 he reported in Buenos Aires that "occasionally (in vitro) the blood of some of the haemophilic patients with a greatly prolonged clotting time…when added to other haemophilic blood possessed a coagulant action nearly as effective as normal blood". This finding would later be known to happen due to the normal level of factor VIII in the plasma of patients with haemophilia B correcting the defect in patients with the much commoner form, haemophilia A.[5]

See also[edit]

References[edit]

  1. ^ a b c d e f "Dr. Alfredo Pavlovsky". fundaleu.org. Retrieved 6 January 2019.
  2. ^ a b "A Brief History of Hemophilia Treatment". hemophilianewstoday.com. 2017-12-12. Retrieved 6 January 2019.
  3. ^ "ANM". acamedbai.org.ar. Retrieved 6 January 2019.
  4. ^ Hougie, Cecil (December 2004). Thrombosis and Bleeding: An Era of Discovery. ISBN 9781412032407.
  5. ^ Giangrande, Paul L. F. (2003). "Six Characters in Search of An Author: The History of the Nomenclature of Coagulation Factors". British Journal of Haematology. 121 (5): 703–712. doi:10.1046/j.1365-2141.2003.04333.x.