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Altizide

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Altizide
Names
IUPAC name
(3R)-6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Other names
  • Althiazide
  • CB 8093
  • P 1779
  • Altizidum
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.024.541 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m1/s1 checkY
    Key: VGLGVJVUHYTIIU-LLVKDONJSA-N checkY
  • InChI=1/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m1/s1
    Key: VGLGVJVUHYTIIU-LLVKDONJBT
  • O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)N[C@@H](N2)CSC\C=C)N
  • C=CCSCC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Properties
C11H14ClN3O4S3
Molar mass 383.89456
Density 1.502 g/mL
Boiling point 625.8 °C (1,158.4 °F; 898.9 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Altizide is a thiazide diuretic. Together with Spironolactone it's sold under the brand name of Aldactacine and Aldactazine by Pfizer and other names by other companies.[1]

Synthesis

Altizide synthesis: J. M. McMannus, GB 902658  (1962).

References

  1. ^ "Altizide". drugs.com.