Aluminium toxicity in people on dialysis

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Aluminium toxicity in people on dialysis

Aluminium toxicity in people on dialysis (or aluminium toxicity) is a problem for people on haemodialysis. The dialysis process does not efficiently remove excess aluminium from the body, so it may build up over time. Aluminium is a potentially toxic metal, and aluminium poisoning may lead to mainly three disorders: aluminium-induced bone disease, microcytic anemia and neurological dysfunction (encephalopathy). Such conditions are more prominently observed in people with chronic renal failure and especially in people on haemodialysis.

About 5–10 mg of aluminium enters our body daily through different sources like water, food, occupational exposure to aluminium in industries etc.[1] In people with normal renal function, serum aluminium is normally lower than 6 microgram/L.[2] Baseline levels of serum aluminium should be <20 microgram/L.[3] According to AAMI standards aluminum levels in the dialysis fluid should be less than 0.01milligram/L.[4]