Amphissa may refer to:
- Amphissa (city), an alternative writing for Amfissa, a town and a former municipality in Phocis, Greece
- Amphissa (gastropod), a small sea snails genus in the family Columbellidae
- Amphissa (mythology), an incest daughter of Aeolus 's son, Macareus, with his sister, Canace, in Greek mythology
- Microvoluta amphissa, a sea snail species
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