Andy Brass

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Andy Brass
Andy Brass P1010738 (13870383443).jpg
Born Andrew M. Brass
United Kingdom
Fields Bioinformatics
Alma mater University of Edinburgh
Thesis Molecular dynamics simulations of fluorite structure crystals (1987)
Doctoral students

Andrew M. Brass is a Professor of Bioinformatics at the University of Manchester in the School of Computer Science and Faculty of Life Sciences.[20][21][22][23][24]


Brass was educated at the University of Edinburgh, receiving his PhD on Solid-state physics in 1987.[25]


Following his PhD, Brass worked at McMaster University[26][27] in Canada on a NATO fellowship to study aspects of high-temperature superconductivity and strongly coupled electron systems. In 1990 he moved to the University of Manchester[28][29] to become a founding member of the bioinformatics group, where he has a wide range of projects in protein function prediction, gene expression analysis, intelligent integration,[30] automated curation,[31] and bioinformatics education.[32]


  1. ^ Fisher, Paul Ryan (2009). Towards a systematic approach to the large-scale analysis of genotype-phenotype correlations (PhD thesis). University of Manchester. 
  2. ^ a b Noyes, H.; Brass, A.; Obara, I.; Anderson, S.; Archibald, A. L.; Bradley, D. G.; Fisher, P.; Freeman, A.; Gibson, J.; Gicheru, M.; Hall, L.; Hanotte, O.; Hulme, H.; McKeever, D.; Murray, C.; Oh, S. J.; Tate, C.; Smith, K.; Tapio, M.; Wambugu, J.; Williams, D. J.; Agaba, M.; Kemp, S. J. (2011). "Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection". Proceedings of the National Academy of Sciences. 108 (22): 9304–9309. PMC 3107286Freely accessible. PMID 21593421. doi:10.1073/pnas.1013486108. 
  3. ^ Fisher, P.; Noyes, H.; Kemp, S.; Stevens, R.; Brass, A. (2009). "A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation". Cardiovascular Genomics. Methods in Molecular Biology. 573. pp. 329–345. ISBN 978-1-60761-246-9. PMID 19763936. doi:10.1007/978-1-60761-247-6_18. 
  4. ^ Rennie, C.; Hulme, H.; Fisher, P.; Halp, L.; Agaba, M.; Noyes, H. A.; Kemp, S. J.; Brass, A. (2008). "A systematic, data-driven approach to the combined analysis of microarray and QTL data". Developments in biologicals. Developments in Biologicals. 132: 293–299. ISBN 978-3-8055-8619-1. PMID 18817316. doi:10.1159/000317174. 
  5. ^ a b Fisher, P.; Hedeler, C.; Wolstencroft, K.; Hulme, H.; Noyes, H.; Kemp, S.; Stevens, R.; Brass, A. (2007). "A systematic strategy for large-scale analysis of genotype phenotype correlations: Identification of candidate genes involved in African trypanosomiasis". Nucleic Acids Research. 35 (16): 5625–5633. PMC 2018629Freely accessible. PMID 17709344. doi:10.1093/nar/gkm623. 
  6. ^ Han, Nam Shik (2013). Systematic approaches for modelling and visualising responses to perturbation of transcriptional regulatory networks (PhD thesis). University of Manchester. 
  7. ^ Ranandeh Kalankesh, Leila (2010). Exploring nature of the structured data in GP electronic patient records (PhD thesis). University of Manchester. 
  8. ^ Kalankesh, L. R.; Stevens, R.; Brass, A. (2012). "The language of gene ontology: A Zipf's law analysis". BMC Bioinformatics. 13: 127. PMC 3473240Freely accessible. PMID 22676436. doi:10.1186/1471-2105-13-127. 
  9. ^ Mallon, Ann-Marie (2004). Comparative analysis of the mouse and human genomes (PhD thesis). University of Manchester. 
  10. ^ Morrison, Norman (2003). Microarray data analysis: a comparison of normalisation techniques and case study (PhD thesis). University of Manchester. 
  11. ^ Tate, Catriona Mary (2010). Effect of probe-target sequence mismatches on the results of microarray hybridisations: position-dependence, modelling and impact of evolutionary distance (PhD thesis). University of Manchester. 
  12. ^ Tipney, Hannah Jane (2006). Bioinformatics as a tool to predict gene function in Williams-Beuren Syndrome (PhD thesis). University of Manchester. 
  13. ^ Hinsley, T. A.; Cunliffe, P.; Tipney, H. J.; Brass, A.; Tassabehji, M. (2009). "Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome". Protein Science. 13 (10): 2588–2599. PMC 2286546Freely accessible. PMID 15388857. doi:10.1110/ps.04747604. 
  14. ^ Stevens, R. D.; Tipney, H. J.; Wroe, C. J.; Oinn, T. M.; Senger, M.; Lord, P. W.; Goble, C. A.; Brass, A.; Tassabehji, M. (2004). "Exploring Williams-Beuren syndrome using myGrid". Bioinformatics. 20: i303–i310. PMID 15262813. doi:10.1093/bioinformatics/bth944. 
  15. ^ Tipney, H. J.; Hinsley, T. A.; Brass, A.; Metcalfe, K.; Donnai, D.; Tassabehji, M. (2004). "Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams–Beuren syndrome". European Journal of Human Genetics. 12 (7): 551–560. PMID 15100712. doi:10.1038/sj.ejhg.5201174. 
  16. ^ Wolstencroft, Katherine Jane (2005). Ontological methods for structuring and managing protein family resources (PhD thesis). University of Manchester. 
  17. ^ Wolstencroft, K.; Lord, P.; Tabernero, L.; Brass, A.; Stevens, R. (2006). "Protein classification using ontology classification". Bioinformatics. 22 (14): e530–e538. PMID 16873517. doi:10.1093/bioinformatics/btl208. 
  18. ^ Wolstencroft, K.; McEntire, R.; Stevens, R.; Tabernero, L.; Brass, A. (2004). "Constructing ontology-driven protein family databases". Bioinformatics. 21 (8): 1685–1692. PMID 15564301. doi:10.1093/bioinformatics/bti158. 
  19. ^ Wolstencroft, K. J.; Stevens, R.; Tabernero, L.; Brass, A. (2004). "PhosphaBase: An ontology-driven database resource for protein phosphatases". Proteins: Structure, Function, and Bioinformatics. 58 (2): 290–294. PMID 15558746. doi:10.1002/prot.20325. 
  20. ^ Andy Brass publications indexed by Google Scholar
  21. ^ List of publications from Microsoft Academic Search
  22. ^ Andy Brass at DBLP Bibliography Server
  23. ^ Andy Brass's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  24. ^ Andy Brass author profile page at the ACM Digital Library
  25. ^ Brass, Andrew (1987). Molecular dynamics simulations of fluorite structure crystals (PhD thesis). University of Edinburgh. 
  26. ^ Jensen, H.; Brass, A.; Berlinsky, A. (1988). "Lattice deformations and plastic flow through bottlenecks in a two-dimensional model for flux pinning in type-II superconductors". Physical Review Letters. 60 (16): 1676–1679. PMID 10038108. doi:10.1103/PhysRevLett.60.1676. 
  27. ^ Jensen, H.; Brass, A.; Brechet, Y.; Berlinsky, A. (1988). "Current-voltage characteristics in a two-dimensional model for flux flow in type-II superconductors". Physical Review B. 38 (13): 9235–9237. doi:10.1103/PhysRevB.38.9235. 
  28. ^ Scott, J. E.; Cummings, C.; Brass, A.; Chen, Y. (1991). "Secondary and tertiary structures of hyaluronan in aqueous solution, investigated by rotary shadowing-electron microscopy and computer simulation. Hyaluronan is a very efficient network-forming polymer". The Biochemical Journal. 274 (Pt 3): 699–705. PMC 1149968Freely accessible. PMID 2012600. doi:10.1042/bj2740699. 
  29. ^ Tuckwell, D. S.; Brass, A.; Humphries, M. J. (1992). "Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site". The Biochemical Journal. 285 (Pt 1): 325–331. PMC 1132784Freely accessible. PMID 1322124. doi:10.1042/bj2850325. 
  30. ^ Lord, P. W.; Stevens, R. D.; Brass, A.; Goble, C. A. (2003). "Investigating semantic similarity measures across the Gene Ontology: The relationship between sequence and annotation". Bioinformatics. 19 (10): 1275–1283. PMID 12835272. doi:10.1093/bioinformatics/btg153. 
  31. ^ Taylor, C. F.; Paton, N. W.; Garwood, K. L.; Kirby, P. D.; Stead, D. A.; Yin, Z.; Deutsch, E. W.; Selway, L.; Walker, J.; Riba-Garcia, I.; Mohammed, S.; Deery, M. J.; Howard, J. A.; Dunkley, T.; Aebersold, R.; Kell, D. B.; Lilley, K. S.; Roepstorff, P.; Yates Jr, J. R.; Brass, A.; Brown, A. J. P.; Cash, P.; Gaskell, S. J.; Hubbard, S. J.; Oliver, S. G. (2003). "A systematic approach to modeling, capturing, and disseminating proteomics experimental data". Nature Biotechnology. 21 (3): 247–254. PMID 12610571. doi:10.1038/nbt0303-247. 
  32. ^ Goble, C. A.; Stevens, R.; Ng, G.; Bechhofer, S.; Paton, N. W.; Baker, P. G.; Peim, M.; Brass, A. (2001). "Transparent access to multiple bioinformatics information sources" (PDF). IBM Systems Journal. 40 (2): 532–551. doi:10.1147/sj.402.0532.