Karl Learmont (ZooG) and Amelia Tan (Destroyx), met on an online zine forum. They shared an interest in zines and started the distro Vox Populis in 2002. They then started making zines for themselves which became the lyrical inspiration for releases to follow. Angelspit was formed in 2003, and the duo then self-released their debut EP, Nurse Grenade on 3 October 2004.
The band self-released their debut studio album, Krankhaus on 6 June 2006, and re-released it on 30 January 2007 with a bonus remix album, entitled Surgically Atoned, and in the US on Dancing Ferret Discs. The album featured remixes by Combichrist and Ego Likeness. A video for "Vena Cava" was released on 22 August 2007. The band toured Australia, the USA and Europe where they lived in Berlin to record their second studio album, Blood Death Ivory.
The band released their second studio album, Blood Death Ivory on 11 June 2008. The album was written and recorded between 2006 and 2008. Again, the band continued to tour the new material around Europe and the USA. They released their debut remix album Black Kingdom Red Kingdom on 15 May 2009. Around this time the band began to produce "Blipverts", short video blogs and tutorials on various topics, including the production of the band's third studio album.
The band released their third studio album, Hideous and Perfect on 9 September 2009. A video for "Fuck the Revolution" was released on 28 September 2009. They released their second remix album Larva Pupa Tank Coffin on 10 October 2010. Larva Pupa Tank Coffin includes 4 brand new Angelspit tracks and remixes by the band themselves as well as other artists. A video for the remix of "Sleep Now" was released on 2 October 2010. They released their third remix album, Carbon Beauty on 8 March 2011. This new remix album contains 3 new tracks as well as 10 remixes of tracks from the Hideous and Perfect album. A video for "Toxic Girl" was released on 13 April 2011, and a video for "Like It? Lick It!" was released on 27 July 2011.
On 15 April 2011, Angelspit announced the addition of three new members: guitarist Valerie Gentile (Black Tape for a Blue Girl, The Crüxshadows), drummer Chris Kling (Hanzel und Gretyl, Mortiis) and videojammer The Liar. The new line-up of Angelspit released their fourth studio album, Hello My Name Is on 11 October 2011. Matt James replaced Chris Kling in early 2012, and former Crüxshadows guitarist George Bikos filled in for Valerie Gentile on the band's 2012 tour. On 23 March 2014, Angelspit announced DestroyX was taking time off to focus on her other projects and would be re-joining Angelspit on future recordings.