Antimotility agents are drugs used to alleviate the symptoms of diarrhea. These include loperamide (Imodium), diphenoxylate with atropine (Lomotil), and opiates such as paregoric tincture of opium, codeine, and morphine. In diarrhea caused by invasive pathogens such as Salmonella, Shigella, and Campylobacter, the use of such agents has generally been strongly discouraged, though evidence is lacking that they are harmful when administered in combination with antibiotics in Clostridium difficile cases. Use of antimotility agents in children and the elderly has also been discouraged in treatment of EHEC (Shiga-like toxin producing Escherichia coli) due to an increased rate of hemolytic uremic syndrome.
- Hoonmo L. Koo; Diana C. Koo; Daniel M. Musher; Herbert L. DuPont. "Antimotility Agents for the Treatment of Clostridium difficile Diarrhea and Colitis" (PDF). CID 2009:48.
- Woo Kyun Bae; Youn Kyoung Lee; Min Seok Cho; Seong Kwon Ma; Soo Wan Kim; Nam Ho Kim; Ki Chul Choi (2006-06-30). "A Case of Hemolytic Uremic Syndrome Caused by Escherichia coli O104:H4". Yonsei Med J. 47 (3): 437–439. PMC . PMID 16807997. doi:10.3349/ymj.2006.47.3.437.
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