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Apalachicola may refer to:
- Apalachicola people, a group of Native Americans who lived along the Apalachicola River in present-day Florida
- Apalachicola, Florida
- Apalachicola River
- Apalachicola Bay
- Apalachicola National Forest
- Apalachicola Regional Airport
- Port of Apalachicola
- Apalachicola (YTB-767), a tugboat in the United States Navy.
| disambiguation page lists articles associated with the title Apalachicola.
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