Appuleia Varilla (flourished 1st century AD) was a Roman noblewoman and the only child of Claudia Marcella Major (niece of Roman emperor Augustus) with her third husband, Sextus Appuleius, consul in 14. Her four older maternal half-siblings were Vipsania Marcella, Lucius Antonius, Gaius Antonius and Iulla Antonia.
In 17, she was charged by Tiberius with adultery and insulting the Roman empress (his mother Livia Drusilla) and his step-father Augustus. In the trial she was acquitted of treason, but her adultery was punished. She was exiled from Rome and ordered not to come within 200 miles of the city. This punishment by relatives was traditional in this circumstance. Manlius, her lover, was banned from Italy and Africa Province.
- Tacitus, The Annals of Imperial Rome: Genealogical Tables - Table 1: Family of Tiberius, p.431
- Tacitus, The Annals of Imperial Rome (Revised Edition) – Translated with an Introduction by Michael Grant, Penguin Books, 1996