Arginine alpha-ketoglutarate

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Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a bodybuilding supplement.[1]

Peer-reviewed studies have found no increase in muscle protein synthesis or improvement in muscle strength from use of AAKG as a dietary supplement.[1][2][3]


  1. ^ a b Wax, B; A Kavazis; H Webb; S Brown (2012). "Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men". Journal of the International Society of Sports Nutrition. 9 (17): 17. doi:10.1186/1550-2783-9-17. PMC 3428651. PMID 22510253.
  2. ^ Willoughby, DS; Boucher T; Reid J; Skelton G; Clark M (Aug 2011). "Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise". International Journal of Sport Nutrition and Exercise Metabolism. 21 (4): 291–9. doi:10.1123/ijsnem.21.4.291. PMID 21813912.
  3. ^ Greer, BK; Jones BT (Jul 2011). "Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training". Journal of Strength and Conditioning Research. 25 (7): 1789–94. doi:10.1519/JSC.0b013e3181e07569. PMID 21399536. S2CID 11182086.