Armen Sarvazyan
Armen Sarvazyan | |
|---|---|
 | |
| Born | July 2, 1939 |
| Alma mater | Moscow State University, Russia |
| Known for | Invention of Shear Wave Elasticity Imaging |
| Scientific career | |
| Fields | Biophysics Biomedical Engineering Elastography |
| Institutions | Institute of Biophysics of the USSR Academy of Sciences Rutgers University, NJ, USA Artann Laboratories, NJ, USA |
Armen Sarvazyan (born July 2, 1939) is a biophysicist and entrepreneur, currently serving as Chief Science Officer of Artann Laboratories. He is most known for his work on the use of shear acoustic waves in medical imaging and diagnostics and the invention of Shear Wave Elasticity Imaging (SWEI).[1][2]
Scientific career
Armen Sarvazyan received the M.S., Ph.D., and D.Sc. degrees in 1964, 1969, and 1983, respectively, from the Moscow State University, Russia, and Institute of Biophysics of the USSR Academy of Sciences. Early in his career, in the 1960s and 1970s, working in the Institute of Biophysics of the USSR Academy of Sciences in Pushchino, he conducted pioneering studies of propagation of shear waves in soft tissues.[3] A couple of decades later, Dr. Sarvazyan proposed a new technology for medical imaging and diagnostics named Shear Wave Elasticity Imaging.[1][2]
In the 1970s and 1980s, in parallel with the studies of soft tissue biomechanics, he developed ultrasonic devices for the investigation of biomolecular interactions and obtained significant results on thermodynamic characteristics of water in the hydration shell of proteins and nucleic acids.[4][5][6]
He continued these studies on the hydration of biopolymers at the Laboratory of Biomolecular Acoustics, which he organized at Rutgers University, NJ, USA in 1992.[7]
Beginning in the late 80s, a significant part of Sarvazyan’s research activities were on the problems of the Elastography, an emerging technology of medical diagnostics. In 1991-1992, in collaboration with the University of Michigan, Ann Arbor, Sarvazyan conducted pioneering experiments on MRI and Ultrasonic Elastography.[8][9][10] He published several review papers on biophysical basis of elasticity imaging, on soft tissue biomechanics and on acoustical radiation force, which is currently the key component in the majority of Elasticity Imaging technologies and devices.[11][12][13][14][15]
During last decade, most of his research activities and publications were on the various medical applications a branch of Elastography called Mechanical Imaging (a.k.a. Tactile Imaging), developed by Sarvazyan with Vladimir Egorov.[16][17][18]
Dr. Sarvazyan has published over 200 research papers and book chapters, and edited 6 books. He has been the Principal Investigator of over 30 research projects funded by NIH, NASA, DoD and Bill and Melinda Gates Foundation. He has over 100 U.S. and international patents and invention certificates. Sarvazyan is the co-founder of several companies specializing in elastography: ProUroCare Medical Inc.(Golden Valley, MN, 1999), Medical Tactile, Inc. (Los Angeles, CA, 2000 ), SuperSonic Imagine (Aix-en-Province, France, 2005) and Advanced Tactile Imaging, Inc. (Trenton, NJ, 2013). He is also the founder of Artann Laboratories. Full list of Dr. Sarvazyan's publications includes 340+ positions. His works have been cited 6,800+ times.
Awards and Honors
Gold Medal at the Exhibition of the Scientific Instruments at the World Fair in Leipzig, Germany (1984)
Silver Medal at the Exhibition NTTM-84, Moscow (1984)
Silver Medal at the Exhibition "Biotechnology-85", Moscow (1985)
Honorary Diploma at the Exhibition "Achievements in Biotechnology", Prague, Czechoslovakia (1988)
Gold Medal of Exhibition of National Economic Achievements of the USSR, Moscow (1988)
AIUM/WFUMB History of Medical Ultrasound Pioneer Award (1988)
Honorary medal and a diploma of the Purkinie University, Brno, Czechoslovakia (1989)
Honorary Diploma of the International Symposium "Ultrasonic Medical Diagnostic Instrumentation and Prospects of Clinical Applications", Moscow (1990)
Best Paper Award at the Tenth IEEE Symposium “Computer Based Medical Systems”, Slovenia (1997)
Best Publication Award for 1997 Russian Academy of Sciences publications in the journals of ‘NAUKA’ Publishing Association, Moscow (1998)
International Professor Emeritus, Physics Department, Moscow State University, Moscow, Russia (2006)
Fellow, Acoustical Society of America (2008)
Helmholtz-Rayleigh Interdisciplinary Silver Medal in Physical Acoustics, Biomedical Acoustics, and Engineering Acoustics awarded by the Acoustical Society of America (2016)
References
- ^ a b Sarvazyan AP, Method and device for shear wave elasticity imaging, USA Patent No 5,606,971, March 4, 1997.
- ^ a b Sarvazyan AP, Rudenko OV, Swanson SD, Fowlkes JB, Emelianov SY, Shear Wave Elasticity Imaging: A new ultrasonic technology of medical diagnostics. Ultrasound Med. Biol. 1998; 24: 1419-1435.
- ^ Sarvazyan AP. Low frequency acoustical characteristics of biological tissues. Mechanics of Polymers 1975; 4: 691-695.
- ^ Sarvazyan A.P. Ultrasonic velocimetry of biological compounds. Annu. Rev. Biophys. Biophys. Chem. 1991; 20: 321-342.
- ^ Buckin VA, Sarvazyan AP, Kharakoz DP. Water near biological molecules. A review. - In: Water in Disperse Systems. Ed. Deryagin BV, Churaev NV, Ovcharenko D, Moscow, Publ. Chemistry, (in Russian), 1989, 45-63.
- ^ Kharakoz DP, Sarvazyan AP. Hydrational and intrinsic compressibilities of globular proteins. Biopolymers, 1993; 33: 11-26.
- ^ Chalikian TV, Sarvazyan AP, Breslauer KJ. Hydration and compressibility of biological solutes. Biophys. Chem. 1994; 51: 89-109.
- ^ Fowlkes J, Emelianov S, Pipe J, Carson P, Adler R, Sarvazyan A, Skovoroda A. Possibility of cancer detection through measurement of elasticity properties. Radiology 1992; 185(P): 206-207.
- ^ Sarvazyan AP, Skovoroda AR, Emelianov SY, Fowlkes JB, Pipe JG, Adler RS, Buxton RB, Carson PL. Biophysical bases of elasticity imaging. In: Acoustical Imaging. Ed. Jones JP, Plenum Press, New York and London, 1995; 21: 223-240.
- ^ Fowlkes JB, Emelianov SY, Pipe JG, Skovoroda AR, Carson PL, Adler RS, and Sarvazyan AP, Magnetic-resonance imaging techniques for detection of elasticity variation. Med Phys, 1995; 22(11): 1771-8.
- ^ Sarvazyan AP. Elastic properties of soft tissues. In: Handbook of Elastic Properties of Solids, Liquids and Gases, Volume III, Chapter 5, eds. Levy M, Bass HE and Stern RR, Academic Press, New York 2001, 107-127.
- ^ Sarvazyan A, Hill CR. Physical chemistry of the ultrasound-tissue interaction. In: Physical Principles of Medical Ultrasonics. 2nd ed. Chichester: John Wiley, Chapter 7, eds. Hill CR, Bamber JC, ter Haar GR, 2004, 223-235.
- ^ Sarvazyan AP, Rudenko OV, Nyborg WL. Biomedical applications of radiation force of ultrasound: Historical roots and physical basis. Review. Ultrasound in Medicine and Biology 2010; 36(9): 1379-1394.
- ^ Sarvazyan A. Diversity of biomedical applications of acoustic radiation force. Review. Ultrasonics 2010, 50(2):230-4.
- ^ Sarvazyan A, Hall TJ, Urban MW, Fatemi M, Aglyamov SR, Garra BS. An overview of Elastography–an emerging branch of medical imaging. Current Medical Imaging Reviews, 2011, 7(4):255-282.
- ^ Sarvazyan AP. Mechanical imaging: a new technology for medical diagnostics. Int. J. Med. Inf. 1998; 49: 195-216.
- ^ Sarvazyan A, Egorov V, and Sarvazyan N. Tactile sensing and tactile imaging in detection of cancer, book chapter In: Biosensors and Molecular Technologies for Cancer Diagnostics, ed. Keith E. Harold, CRC Press, May 29, 2012, 339-354.
- ^ Sarvazyan A, Egorov V. Mechanical Imaging – a technology for 3-D visualization and characterization of soft tissue abnormalities: a review. Current Medical Imaging Reviews, 2012, 8(1):64-73.