Astragaloside

Chemical structure of astragaloside IV

Astragalosides are a series of related chemical compounds isolated from Astragalus membranaceus.

Chemical properties of AS

astrasieversianin also known as AS-IV, astraversianin XIV, or cyclosiversioside F. AS-IV is a white powder with a melting point of 284°C–285°C (Wang et al., 1987). Its molecular formula is C₄₁H₆₈O₁₄, and its theoretically accurate molecular weight is 784.4609 (Kitagawa et al., 1983.

(ASTs) have been traditionally used in the treatment of various cardiovascular and cerebrovascular diseases. The aim of the present study was to investigate the neuroprotective effects of AST on learning and memory following focal cerebral ischemia/reperfusion in a rat model. A Morris water maze was used to measure the effect of AST on learning and memory impairments. A histological examination and Hoechst 33258 staining was used to observe the neuronal changes and apoptosis in the hippocampus. The activity of phospho-extracellular signal‑regulated kinases (p‑ERK), p‑c-Jun N-terminal kinases (JNK) and p‑Akt was measured by western blotting. The data revealed that AST improved the rats learning and memory abilities, attenuated neuronal cells apoptosis, increased the expression of p‑ERK and p‑Akt, and decreased the expression of p‑JNK [3]

References

2. ^ Wang, P. P., Xu, D. J., Huang, C., Wang, W. P., and Xu, W. K. (2014). Astragaloside - reduces the expression level of P-glycoprotein in multidrug-resistant human hepatic cancer cell lines. Mol. Med. Rep. 9, 2131–2137. doi:10.3892/mmr.2014.2074

3. ^ Wu YY, Wu WY, Gong HL, Li WZ, Yin YY. Astragalosides attenuate learning and memory impairment in rats following ischemia‑reperfusion injury. Mol Med Rep. 2014 Apr;9(4):1319-24. doi: 10.3892/mmr.2014.1969. Epub 2014 Feb 19. PMID: 24567111.