Bacteriophage scaffolding proteins

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Scaffold protein B
PDB 1cd3 EBI.jpg
procapsid of bacteriophage phix174
Symbol Phage_B
Pfam PF02304
InterPro IPR003513
SCOP 1cd3
Bacteriophage scaffolding protein D
PDB 1tx9 EBI.jpg
gpd prior to capsid assembly
Symbol gpD
Pfam PF02925
InterPro IPR004196
SCOP 1al0

In molecular biology, bacteriophage scaffolding proteins are proteins involved in bacteriophage assembly.

The assembly of a macromolecular structure proceeds via a specific pathway of ordered events and involves conformational changes in the proteins as they join the assembly. The assembly process is aided by scaffolding proteins, which act as chaperones. In bacteriophage, scaffolding proteins B and D are responsible for procapsid formation. 240 copies of protein D form the external scaffold, while 60 copies of protein B form the internal scaffold.[1] The role of scaffolding protein D is in the production of viral single-stranded RNA.


  1. ^ Dokland T, McKenna R, Ilag LL, Bowman BR, Incardona NL, Fane BA, Rossmann MG (September 1997). "Structure of a viral procapsid with molecular scaffolding". Nature. 389 (6648): 308–13. doi:10.1038/38537. PMID 9305849. 

This article incorporates text from the public domain Pfam and InterPro IPR004196

This article incorporates text from the public domain Pfam and InterPro IPR003513