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Bacteriophage scaffolding proteins

From Wikipedia, the free encyclopedia
Scaffold protein B
procapsid of bacteriophage phix174
Identifiers
SymbolPhage_B
PfamPF02304
InterProIPR003513
SCOP21cd3 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Bacteriophage scaffolding protein D
gpd prior to capsid assembly
Identifiers
SymbolgpD
PfamPF02925
InterProIPR004196
SCOP21al0 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, bacteriophage scaffolding proteins are proteins involved in bacteriophage assembly.

The assembly of a macromolecular structure proceeds via a specific pathway of ordered events and involves conformational changes in the proteins as they join the assembly. The assembly process is aided by scaffolding proteins, which act as chaperones. In bacteriophage, scaffolding proteins B and D are responsible for procapsid formation. 240 copies of protein D form the external scaffold, while 60 copies of protein B form the internal scaffold.[1] The role of scaffolding protein D is in the production of viral single-stranded RNA.

References

[edit]
  1. ^ Dokland T, McKenna R, Ilag LL, Bowman BR, Incardona NL, Fane BA, Rossmann MG (September 1997). "Structure of a viral procapsid with molecular scaffolding". Nature. 389 (6648): 308–13. doi:10.1038/38537. PMID 9305849. S2CID 4387862.
This article incorporates text from the public domain Pfam and InterPro: IPR004196
This article incorporates text from the public domain Pfam and InterPro: IPR003513