Barbara J. Meyer

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Barbara J. Meyer
Born 1949
Alma mater
Spouse(s) Tom Cline
Scientific career

Barbara J. Meyer (born 1949) is a biologist, noted for her pioneering research on lambda phage, a virus that infects bacteria; discovery of the master control gene involved in sex determination; and studies of gene regulation, particularly dosage compensation.


Meyer completed her undergraduate BS at Stanford University, working with David Clayton. She began her Ph.D. at the University of California, Berkeley and completed it in 1979 at Harvard University in the lab of Mark Ptashne, working on gene regulation in lambda phage—ultimately publishing thirteen papers as a graduate student.[1]

Meyer then did a postdoc at Cambridge University, in the MRC Laboratory of Molecular Biology, in Sydney Brenner's lab, switching from bacteria to Caenorhabditis elegans, a roundworm. Still studying gene regulation, but turning to sex determination, Meyer discovered the master gene involved in sex determination.

Meyer was tenured at M.I.T.. She accepted a full faculty appointment at the University of California, Berkeley, in 1990.

Meyer is married to fellow biologist Tom Cline.[1]

Notable papers[edit]

  • Clustered DNA Motifs Mark X Chromosomes for Repression by a Dosage Compensation Complex. [P. McDonel, J. Jans, B. Peterson, B. Meyer (2006) Nature 444, 614-618]
  • Sperm Chromatin Proteomics Identifies Evolutionarily Conserved Fertility Factors. [D. Chu, H. Liu, P. Nix, T. Wu, E. Ralston, J. Yates, B. Meyer (2006) Nature 443, 101-105]
  • "Vive la difference: males vs females in flies vs worms" (Review article), TW Cline, BJ Meyer - Annu. Rev. Genet, 1996
  • Barbara J. Meyer, Dennis G. Kleid, and Mark Ptashne, "Lambda Repressor Turns Off Transcription of Its Own Gene", PNAS, v.72, n.12, pp. 4785–4789 (Dec. 1975).




External links[edit]