Blaise ketone synthesis

The Blaise ketone synthesis (named after Edmond E. Blaise) is the chemical reaction of acid chlorides with organozinc compounds to give ketones.^{[1] [2]}

The Blaise ketone synthesis

The reaction also works with organocuprates.^[3][4]

Reviews have been written.^{[5] [6]}

Variations

Blaise-Maire reaction

The Blaise-Maire reaction is the Blaise ketone synthesis using β-hydroxy acid chlorides to give β-hydroxyketones, which are converted into α,β-unsaturated ketones using sulfuric acid.^[7]

See also

• Blaise reaction

References

1. ^ Blaise, E. E.; Koehler, A. (1910). Bull. Soc. Chim. 7: 215. {{cite journal}}: Missing or empty |title= (help)CS1 maint: multiple names: authors list (link)
2. ^ Blaise, E. E. (1911). Bull. Soc. Chim. 9: 1. {{cite journal}}: Missing or empty |title= (help)
3. ^ Posner, G. H.; Whitten, C. E. (1976). "Secondary and Tertiary Alkyl Ketones from Carboxylic Acid Chlorides and Lithium Phenylthio(Alkyl)Cuprate Reagents: tert-Butyl Phenyl Ketone". Organic Syntheses. 55: 122{{cite journal}}: CS1 maint: multiple names: authors list (link); Collected Volumes, vol. 6, p. 248.
4. ^ Fujisawa, T.; Sato, T. (1988). "Ketones from Carboxylic Acids and Grignard Reagents: Methyl 6-Oxodecanoate". Organic Syntheses. 66: 116{{cite journal}}: CS1 maint: multiple names: authors list (link); Collected Volumes, vol. 8, p. 441.
5. ^ Cason, J. (1947). "The Use of Organocadmium Reagents for the Preparation of Ketones". Chem. Rev. 40 (1): 17. doi:10.1021/cr60125a002. PMID 20287882.
6. ^ Shirley, D. A. (1954). "The Synthesis of Ketones from Acid Halides and Organometallic Compounds of Magnesium, Zinc, and Cadmium". Org. React. 8: 29. doi:10.1002/0471264180.or008.02. ISBN 0471264180.
7. ^ Blaise, E. E.; Maire, M. (1907). Compt. Rend. 145: 73. {{cite journal}}: Missing or empty |title= (help)CS1 maint: multiple names: authors list (link)