Bleb may refer to:
- Bleb (cell biology), an irregular bulge in the plasma membrane of a cell
- Bleb (medicine), a large blister filled with serous fluid, or jargon for an outpouching of any kind, from a vessel (see Aneurysm), or in the lungs (see Pneumothorax).
- Bleb (mineralogy), a small bubble-like inclusion of one mineral within a larger mineral
- Bleb, a book of poetry written by B-52's frontman Fred Schneider
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