BolA-like protein family

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BolA
PDB 1ny8 EBI.jpg
solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115
Identifiers
Symbol BolA
Pfam PF01722
InterPro IPR002634
SCOP 1v9j
SUPERFAMILY 1v9j

In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli, the Fra2 protein from Saccharomyces cerevisiae, and various homologs. The BolA protein is a DNA-binding regulator;[1] the Fra2 protein is an iron sulfur cluster protein that binds Grx3/4 and is involved in regulating iron levels .[2]

In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.[3] The expression of BolA is growth rate regulated and is induced during the transition into the stationary phase.[3] BolA is also induced by stress during early stages of growth [3] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.[3][4]

References[edit]

  1. ^ Dressaire C, Moreira RN, Barahona S, Alves de Matos AP, Arraiano CM, Santos JM, Freire P, Vicente M, Arraiano CM (17 February 2015). "BolA Is a Transcriptional Switch That Turns Off Motility and Turns On Biofilm Development". mBio 6 (1): e02352–14. doi:10.1128/mBio.02352-14. PMID 25691594. 
  2. ^ Haoran Li, Daphne T. Mapolelo, Nin N. Dingra, Sunil G. Naik, Nicholas S. Lees, Brian M. Hoffman, Pamela J. Riggs-Gelasco, Boi Hanh Huynh, Michael K. Johnson and Caryn E. Outten (August 28, 2009). "The Yeast Iron Regulatory Proteins Grx3/4 and Fra2 Form Heterodimeric Complexes Containing a [2Fe-2S] Cluster with Cysteinyl and Histidyl Ligation". Biochemistry 48 (40): pp 9569–9581. doi:10.1021/bi901182w. PMID 19715344. 
  3. ^ a b c d Santos JM, Freire P, Vicente M, Arraiano CM (May 1999). "The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth". Mol. Microbiol. 32 (4): 789–98. doi:10.1046/j.1365-2958.1999.01397.x. PMID 10361282. 
  4. ^ Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR (December 1989). "Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene". EMBO J. 8 (12): 3923–31. PMC 402084. PMID 2684651. 

This article incorporates text from the public domain Pfam and InterPro IPR002634