BolA-like protein family

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PDB 1ny8 EBI.jpg
solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115

In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli, the Fra2 protein from Saccharomyces cerevisiae, and various homologs. The BolA protein is a DNA-binding regulator;[1] the Fra2 protein is an iron sulfur cluster protein that binds Grx3/4 and is involved in regulating iron levels .[2]

In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.[3] The expression of BolA is growth rate regulated and is induced during the transition into the stationary phase.[3] BolA is also induced by stress during early stages of growth [3] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.[3][4]


  1. ^ Dressaire C, Moreira RN, Barahona S, Alves de Matos AP, Arraiano CM, Santos JM, Freire P, Vicente M, Arraiano CM (17 February 2015). "BolA Is a Transcriptional Switch That Turns Off Motility and Turns On Biofilm Development". mBio. 6 (1): e02352-14. doi:10.1128/mBio.02352-14. PMC 4337573. PMID 25691594.
  2. ^ Li H, Mapolelo DT, Dingra NN, Naik SG, Lees NS, Hoffman BM, Riggs-Gelasco PJ, Huynh BH, Johnson MK, Outten CE (2009). "The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation". Biochemistry. 48 (40): 9569–81. doi:10.1021/bi901182w. PMC 2796373. PMID 19715344.
  3. ^ a b c d Santos JM, Freire P, Vicente M, Arraiano CM (May 1999). "The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth". Mol. Microbiol. 32 (4): 789–98. doi:10.1046/j.1365-2958.1999.01397.x. PMID 10361282.
  4. ^ Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR (December 1989). "Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene". EMBO J. 8 (12): 3923–31. PMC 402084. PMID 2684651.
This article incorporates text from the public domain Pfam and InterPro: IPR002634