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Bone marrow-derived macrophage

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Bone-marrow-derived macrophage (BMDM) refers to macrophage cells that are generated in a research laboratory from mammalian bone marrow cells. Undifferentiated bone marrow cells are cultured in the presence of macrophage colony-stimulating factor (M-CSF; CSF1).[1] M-CSF is a cytokine that directs cell differentiation. These cells are often used in immunology and cell biology research.[2]

References

  1. ^ Weischenfeldt, Joachim; Porse, Bo (2008-12-01). "Bone Marrow-Derived Macrophages (BMM): Isolation and Applications". Cold Spring Harbor Protocols. 2008 (12): pdb.prot5080. doi:10.1101/pdb.prot5080. ISSN 1940-3402. PMID 21356739.
  2. ^ oshizawa, S., et al. "Legionella Pneumophila Evades Gamma Interferon-Mediated Growth Suppression through Interleukin-10 Induction in Bone Marrow-Derived Macrophages." Infection and Immunity 73.5 (2005): 2709-17.


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