M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.
M-CSF released by osteoblasts (as a result of endocrine stimulation by parathyroid hormone) exerts paracrine effects on osteoclasts. M-CSF binds to receptors on osteoclasts inducing differentiation, and ultimately leading to increased plasma calcium levels—through the resorption (breakdown) of bone. Additionally, high levels of CSF-1 expression are observed in the endometrial epithelium of the pregnant uterus as well as high levels of its receptor CSF1R in the placental trophoblast. Studies have shown that activation of trophoblasitc CSF1R by local high levels of CSF-1 is essential for normal embryonic implantation and placental development. More recently, it was discovered that CSF-1 and its receptor CSF1R are implicated in the mammary gland during normal development and neoplastic growth.
Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.
M-CSF has been described to play a role in renal pathology including acute kidney injury and chronic renal failure. The chronic activation of monocytes can lead to multiple metabolic, hematologic and immunologic abnormalities in patients with chronic renal failure. In the context of acute kidney injury, M-CSF has been implicated in promoting repair following injury, but also been described in an opposing role, driving proliferation of a pro-inflammatory macrophage phenotype.
Pandit J, Bohm A, Jancarik J, Halenbeck R, Koths K, Kim SH (1993). "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor". Science258 (5086): 1358–62. doi:10.1126/science.1455231. PMID1455231.
Suzu S, Ohtsuki T, Yanai N, Takatsu Z, Kawashima T, Takaku F, Nagata N, Motoyoshi K (1992). "Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species". J. Biol. Chem.267 (7): 4345–8. PMID1531650.
Saltman DL, Dolganov GM, Hinton LM, Lovett M (1992). "Reassignment of the human macrophage colony stimulating factor gene to chromosome 1p13-21". Biochem. Biophys. Res. Commun.182 (3): 1139–43. doi:10.1016/0006-291X(92)91850-P. PMID1540160.
Praloran V, Chevalier S, Gascan H (1992). "Macrophage colony-stimulating factor is produced by activated T lymphocytes in vitro and is detected in vivo in T cells from reactive lymph nodes". Blood79 (9): 2500–1. PMID1571567.
Price LK, Choi HU, Rosenberg L, Stanley ER (1992). "The predominant form of secreted colony stimulating factor-1 is a proteoglycan". J. Biol. Chem.267 (4): 2190–9. PMID1733926.
Pampfer S, Tabibzadeh S, Chuan FC, Pollard JW (1992). "Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1". Mol. Endocrinol.5 (12): 1931–8. doi:10.1210/mend-5-12-1931. PMID1791839.
Stein J, Borzillo GV, Rettenmier CW (1990). "Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1". Blood76 (7): 1308–14. PMID2145044.
Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1". Cell41 (3): 665–76. doi:10.1016/S0092-8674(85)80047-7. PMID2408759.
Cerretti DP, Wignall J, Anderson D, Tushinski RJ, Gallis BM, Stya M, Gillis S, Urdal DL, Cosman D (1988). "Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene". Mol. Immunol.25 (8): 761–70. doi:10.1016/0161-5890(88)90112-5. PMID2460758.
Takahashi M, Hirato T, Takano M, Nishida T, Nagamura K, Kamogashira T, Nakai S, Hirai Y (1989). "Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF". Biochem. Biophys. Res. Commun.161 (2): 892–901. doi:10.1016/0006-291X(89)92683-1. PMID2660794.
Kawasaki ES, Ladner MB, Wang AM, Van Arsdell J, Warren MK, Coyne MY, Schweickart VL, Lee MT, Wilson KJ, Boosman A (1985). "Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1)". Science230 (4723): 291–6. doi:10.1126/science.2996129. PMID2996129.
Takahashi M, Hong YM, Yasuda S, Takano M, Kawai K, Nakai S, Hirai Y (1988). "Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis". Biochem. Biophys. Res. Commun.152 (3): 1401–9. doi:10.1016/S0006-291X(88)80441-8. PMID3259875.