|Publisher(s)||Brain Chain Games, Inc.|
|Players||2–3 players or teams|
|Age range||8 +|
|Setup time||3 minutes|
|Playing time||30–90 minutes|
|Skill(s) required||Abstract Strategy, Teamwork, General knowledge, Social Skills|
Brain Chain is a strategy-driven trivia board game played by two or three players or teams. The object is to be the first player or team to connect an unbroken row of six "links" horizontally, vertically, or diagonally. The game is played on a 10x10 category grid surrounded by an exterior track. Brain Chain has been described as Trivial Pursuit with a Go-Moku win mechanic plus a dash of Pueblo added in.
Brain Chain was designed by Alicia Vaz and Scot Blackburn, who are Los Angeles attorneys, and Kris Harter, a graduate of Pacific Union College and  a teacher at Loma Linda Academy. Roy Ice designed all of the graphics on the gameboard and box. Brigit Warner edited all of the trivia questions. Brain Chain is currently owned and distributed by Brain Chain Games, Inc.
Before play begins, the players agree on the number of links necessary to win the game. A game of Brain Chain takes approximately 30 minutes if the goal is four links in a row, an hour if the goal is five links, or 90 minutes if the winning condition is a six-link chain.
Each turn begins with the playing of one movement card and as many Brain Pills as the player wishes and moving the playing pawn, clockwise, the corresponding number of spaces. All players move the same yellow playing pawn. If the pawn does not land on one of the four corner squares, the player then picks a trivia category from the same horizontal row or vertical column as the pawn that is not already occupied by a link. The opposing team will then read a trivia question from the selected category. The player may consult his or her team, but only the player whose turn it is may announce the "final answer." If answered correctly, that player places a link on the chosen square in the category grid and takes a Brain Pill.
If the pawn is moved to one of the four strategic corner squares, instead of picking a category on the row or column the pawn indicates, the player simply follows the instructions on that corner space: Pick any square on the board to answer a question, add a link, remove a link, or move a link.
To create a Brain Chain and win the game a player or team must form an unbroken line of six links in a row vertically, horizontally or diagonally on the Category Grid. The yellow playing pawn is considered a link during a player's turn—allowing a team to win by connecting five links on the border of the grid and moving the pawn to connect with those links.
Trivia Questions and Answers
Each Brain Chain trivia set consists of approximately 3,200 trivia questions and answers which are divided among eight categories: Business, Entertainment, Geography, History, Science, Sports, Potluck and Oddball.
I.D. Category Name Types of Questions Asked BIZ Business Mergers and acquisitions, stocks and bonds, money and currency, product lines, marketing, advertising slogans, accounting, finance, transportation, business law and management. ENT Entertainment Movies, television, books, fine art, pop culture, media and news. GEO Geography World and U.S. geography, people of the world, customs, languages and religions. HIS History World and U.S. history, law, government, the military and politics. SCI Science Inventors and inventions, anatomy, biology, chemistry, physics, weather, astronomy, space exploration, technology, nature, the environment, telecom, mathematics and psychology. SPO Sports Vast array of questions covering professional, amateur, college, international or Olympic sports. POT Potluck This is a random "catch-all" category and may include questions from any of the above categories or other general knowledge questions. ODD Oddball Oddball questions are different from all of the above. Each Oddball question consists of four alternatives; three of them with some positive trait in common. The fourth one does not connect with the others. The answer identifies the one that does not fit with a brief explanation of the positive connection between the other three. PLA Player's Choice Allows the player to choose from any of the above eight categories. OPP Opponent's Choice Allows the player's opponent to choose the category of question asked.
- "BoardGameGeek, Review of Brain Chain, October 2, 2006".
- The Winter Olympics are over but the Competition Continues with Brain Chain, the Awesome Strategy-Meets-Trivia Board Game, March 2006, located at http://www.24-7pressrelease.com/pdf/2006/03/07/press_release_11758.pdf
- Pacific Union College, Website article, November 2006, Award-Winning Gamemakers Credit Success to PUC Education, located at http://www.puc.edu/PUC/newsevents/news/2006/20060110_brain.shtml
- Loma Linda Academy Mirror, Volume 72 Number 4, January/February 2005, Briefs: Brain Chain, located at http://www.lla.org/pdf/mirror/jan_feb_05.pdf Archived October 9, 2006, at the Wayback Machine.
- The Southwesterner Online, December 2006, SWAU Alumna Edits Top 100 Board Game, located at http://southwesterner.swau.edu/index/news-app/story.54/title.swau-alumna-edits-top-100-board-game
- The Luding Database, Game Database Entry, Brain Chain, November 2006, located at http://sunsite.informatik.rwth-aachen.de/cgi-bin/luding/GameName.py?lang=e&gamename=Brain+Chain
- GAMES Magazine, December 2006 Issue, The 2007's Buyer's Guide to Games/Top 100 Traditional Games List, at page 46
- Curio City Online, January 2007, Brain Chain Trivia Strategy Game, located at http://www.curiocityonline.com/index.php/action/item/id/443/prevaction/category/previd/4/prevstart/0/
- Funagain Games, Review by Larry Allen, posted on October 18, 2006, located online at http://www.funagain.com/control/product/~product_id=016565
- Brain Chain Official Rules