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Bubble boy, boy in the bubble or boy in the plastic bubble may refer to:
- Severe combined immunodeficiency, sometimes called bubble boy disease, a genetic disorder which results in an extreme vulnerability to infectious diseases
- Ted DeVita (1962–1980), a victim of severe aplastic anaemia who was forced to live in a sterile hospital room
- David Vetter (1971–1984), a victim of severe combined immune deficiency syndrome who was forced to live in a sterile environment
- The Boy in the Plastic Bubble, a 1976 film starring John Travolta
- "Bubble Boy", an episode of The Powerpuff Girls
- "The Boy in the Bubble", a 1986 song by Paul Simon from the album Graceland
- "The Bubble Boy" (Seinfeld), a 1992 episode of the Seinfeld TV series
- The Boy in the Bubble, British children's novel by Ian Strachan, winner of the 1994 Children's Book Award
- Bubble Boy (film), a 2001 film starring Jake Gyllenhaal
- Bubble Boy (musical), a musical first performed in 2008 and written by the same authors as the film
| disambiguation page lists articles associated with the title Bubble Boy.
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