Bufuralol

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Bufuralol
Bufuralol.svg
Names
Preferred IUPAC name
2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethan-1-ol
Other names
2-(tert-Butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol
2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
Identifiers
3D model (Jmol)
ChemSpider
ECHA InfoCard 100.053.720
UNII
Properties
C16H23NO2
Molar mass 261.37 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity.[1] It is metabolized by CYP2D6.[2]

Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor.

References[edit]

  1. ^ Pringle, TH; Francis, RJ; East, PB; Shanks, RG (1986). "Pharmacodynamic and pharmacokinetic studies on bufuralol in man". British Journal of Clinical Pharmacology. 22 (5): 527–34. doi:10.1111/j.1365-2125.1986.tb02931.x. PMC 1401192Freely accessible. PMID 2878678. 
  2. ^ Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine.  Retrieved on July 2011