Caldesmon

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CALD1
Identifiers
AliasesCALD1, CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22, caldesmon 1
External IDsHomoloGene: 137424 GeneCards: CALD1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CALD1
Genomic location for CALD1
Band7q33Start134,744,252 bp[1]
End134,970,729 bp[1]
RNA expression pattern
PBB GE CALD1 201617 x at fs.png

PBB GE CALD1 201616 s at fs.png

PBB GE CALD1 201615 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004342
NM_033138
NM_033139
NM_033140
NM_033157

n/a

RefSeq (protein)

NP_004333
NP_149129
NP_149130
NP_149131
NP_149347

n/a

Location (UCSC)Chr 7: 134.74 – 134.97 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Caldesmon is a protein that in humans is encoded by the CALD1 gene.[3][4]

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.[4] }}

Immunochemistry[edit]

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122786 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem. 266 (25): 16917–24. PMID 1885618.
  4. ^ a b "Entrez Gene: CALD1 caldesmon 1".

Further reading[edit]

External links[edit]