CCDC104

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Coiled-coil domain containing 104 is a protein that in humans is encoded by the CCDC104 gene.[1]

Model organisms[edit]

Model organisms have been used in the study of CCDC104 function. A conditional knockout mouse line, called Ccdc104tm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty one tests were carried out on homozygous mutant mice and one significant abnormality was observed: increased susceptibility to Citrobacter infection.[4]

References[edit]

  1. ^ "Coiled-coil domain containing 104". Retrieved 2011-12-06. 
  2. ^ "Salmonella infection data for Ccdc104". Wellcome Trust Sanger Institute. 
  3. ^ "Citrobacter infection data for Ccdc104". Wellcome Trust Sanger Institute. 
  4. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". 
  7. ^ "Mouse Genome Informatics". 
  8. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  9. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  10. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353. 

Further reading[edit]

  • Totland, C.; Bredholt, G.; Haugen, M.; Haukanes, B. R. I.; Vedeler, C. A. (2009). "Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo)". Cancer Immunology, Immunotherapy. 59 (2): 231–237. doi:10.1007/s00262-009-0742-3. PMID 19680650.