CLEC5A

CLEC5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YHF
Identifiers
Aliases	CLEC5A, CLECSF5, MDL-1, MDL1, C-type lectin domain family 5 member A, C-type lectin domain containing 5A
External IDs	OMIM: 604987; MGI: 1345151; HomoloGene: 8302; GeneCards: CLEC5A; OMA:CLEC5A - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	141,947,007 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	40,562,755 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; trabecular bone; ; monocyte; ; testicle; ; right coronary artery; ; granulocyte; ; upper lobe of left lung; ; tibial nerve; ; Descending thoracic aorta;
	Top expressed in
	granulocyte; ; embryo; ; bone marrow; ; tibiofemoral joint; ; stroma of bone marrow; ; lumbar subsegment of spinal cord; ; calvaria; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding; virus receptor activity; protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; cell surface; specific granule membrane; tertiary granule membrane; cytosol; plasma membrane;
Biological process	cellular defense response; myeloid cell differentiation; negative regulation of myeloid cell apoptotic process; viral process; signal transduction; immune system process; viral entry into host cell; negative regulation of apoptotic process; osteoblast development; innate immune response; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	23601
	23845
	ENSG00000258227
	ENSMUSG00000029915
	Q9NY25
	Q9R007
	NM_001301167; NM_013252
	NM_001038604; NM_021364
	NP_001288096; NP_037384
	NP_001033693; NP_067339
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 5 member A or CLEC5A, also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL1) is a C-type lectin that in humans is encoded by the CLEC5A gene.^[5]^[6] It appears to be a member of a significant myeloid lineage activating pathway.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000258227 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029915 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: C-type lectin domain family 5".
^ Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (August 1999). "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9792–6. doi:10.1073/pnas.96.17.9792. PMC 22289. PMID 10449773.

Joyce-Shaikh B; et al. (2010). "Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis". J Exp Med. 207 (3): 579–89. doi:10.1084/jem.20090516. PMC 2839155. PMID 20212065.
Chen ST, Lin YL, Huang MT, et al. (2008). "CLEC5A is critical for dengue-virus-induced lethal disease". Nature. 453 (7195): 672–6. doi:10.1038/nature07013. PMID 18496526.
Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
Watson AA, O'Callaghan CA (2010). "Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (Pt 1): 29–31. doi:10.1107/S1744309109047915. PMC 2805530. PMID 20057064.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000258227 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029915 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C-type lectin domain family 5".

[pmid10449773-6] Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (August 1999). "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9792–6. doi:10.1073/pnas.96.17.9792. PMC 22289. PMID 10449773.

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References

Further reading