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COASY

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Template:PBB Bifunctional coenzyme A synthase is an enzyme that in humans is encoded by the COASY gene.[1][2][3]

Template:PBB Summary

Interactions

COASY has been shown to interact with P70-S6 Kinase 1.[4] In 2009, COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.[5]

References

  1. ^ Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A (Jun 2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics". J Biol Chem. 277 (24): 21431–9. doi:10.1074/jbc.M201708200. PMID 11923312.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  2. ^ Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT (Jun 2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis". J Biol Chem. 277 (25): 22107–10. doi:10.1074/jbc.C200195200. PMID 11980892.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  3. ^ "Entrez Gene: COASY Coenzyme A synthase".
  4. ^ Nemazanyy, Ivan; Panasyuk Ganna; Zhyvoloup Alexander; Panayotou George; Gout Ivan T; Filonenko Valeriy (Dec 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Lett. 578 (3). Netherlands: 357–62. doi:10.1016/j.febslet.2004.10.091. ISSN 0014-5793. PMID 15589845. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  5. ^ Breus, Oksana; Panasyuk G; Gout IT; Filonenko V; Nemazanyy I (May 2009). "CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway". Biochem Biophys Res Commun. 385 (4): 581–5. doi:10.1016/j.bbrc.2009.05.102. PMID 19482007. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Further reading

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