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Carboxytherapy is a non-surgical cosmetic medicine treatment for dermatology.[1] Carboxytherapy employs injections or transdermal application to infuse gaseous carbon dioxide below the skin into the subcutaneous tissue through a needle or skin. It has a necrotizing effect on fat tissue fat cells, stimulates blood flow, improves the skin's elasticity and reduces the appearance of cellulite.[2] It has also become a popular treatment for stretch marks.[3] It is non-toxic and less invasive than operations like liposuction.[4] Carboxytherapy leads to a temporary decrease in subcutaneous fat but has shown to reoccur again after a 28 week period.[5] It can be applied for those with androgenic alopecia or alopecia areata.[6]

As of 2018, Carboxytherapy has not approved by the FDA.[4] Risks include inadvertent lipolysis and emphysema.[7]

Carboxytherapy was discovered in 1932 in Royat, France after patients had been soaking in carbon-rich pools with wounds healing and circulatory diseases improving such as Raynaud's syndrome.[8] In the 1950s French doctors began injecting carbon dioxide for treating cellulite.[4]


See also[edit]


  1. ^ Padideh (2024-07-09). "کربوکسی‌تراپی". گروه آموزشی پدیده (in Persian). Retrieved 2024-07-10.
  2. ^ Koutná N (2006). "[Carboxytherapy--a new non-invasive method in aesthetic medicine]" [Carboxytherapy – A New Non-invasive Method in Aesthetic Medicine]. Casopis Lekaru Ceskych (in Czech). 145 (11): 841–843. PMID 17168416.
  3. ^ Prendergast, Peter M.; Shiffman, Melvin A. (2011). Aesthetic Medicine: Art and Techniques. Springer Science & Business Media. p. 554. ISBN 978-3-642-20113-4.
  4. ^ a b c "Carbon dioxide injections might seem better than liposuction—but there's a catch". 20 June 2018.
  5. ^ Alam M, Sadhwani D, Geisler A, Aslam I, Makin IR, Schlessinger DI, et al. (August 2018). "Subcutaneous infiltration of carbon dioxide (carboxytherapy) for abdominal fat reduction: A randomized clinical trial". Journal of the American Academy of Dermatology. 79 (2): 320–326. doi:10.1016/j.jaad.2018.04.038. PMID 29698710. S2CID 13798523.
  6. ^ Doghaim NN, El-Tatawy RA, Neinaa YM, Abd El-Samd MM (December 2018). "Study of the efficacy of carboxytherapy in alopecia". Journal of Cosmetic Dermatology. 17 (6): 1275–1285. doi:10.1111/jocd.12501. PMID 29460509. S2CID 3439462.
  7. ^ a b c d e f g Kroumpouzos G, Arora G, Kassir M, Galadari H, Wollina U, Lotti T, et al. (2022). "Carboxytherapy in dermatology". Clinics in Dermatology. 40 (3): 305–309. doi:10.1016/j.clindermatol.2021.08.020. PMID 35667826. S2CID 238736083.
  8. ^ "Padideh Aesthetic group".
  9. ^ a b c d e f g Kołodziejczak A, Podgórna K, Rotsztejn H (September 2018). "Is carboxytherapy a good alternative method in the removal of various skin defects?". Dermatologic Therapy. 31 (5): e12699. doi:10.1111/dth.12699. PMID 30155955. S2CID 52113929.
  10. ^ Medrano K, Arruda S, Oza N, Sadick N (April 2021). "Carboxytherapy Mask as Post Nanofractional Radiofrequency Treatment for Improvement of Facial Skin Quality and Photoaging". Journal of Drugs in Dermatology. 20 (4): 461–465. doi:10.36849/JDD.5856. PMID 33852250. S2CID 242956193.
  11. ^ Ahramiyanpour N, Shafie'ei M, Sarvipour N, Amiri R, Akbari Z (May 2022). "Carboxytherapy in dermatology: A systematic review". Journal of Cosmetic Dermatology. 21 (5): 1874–1894. doi:10.1111/jocd.14834. PMID 35124882. S2CID 246632396.
  12. ^ Elmorsy EH, Elgarem YF, Sallam ES, Taha AA (November 2021). "Fractional Carbon Dioxide Laser Versus Carboxytherapy in Treatment of Striae Distensae". Lasers in Surgery and Medicine. 53 (9): 1173–1179. doi:10.1002/lsm.23418. PMID 33998005. S2CID 234746340.

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