Sprengel worked under Albrecht Thaer (1752–1828) in Celle. He then worked from 1804 to 1808 with Heinrich Einhof (1778–1808) in Möglin on agricultural studies. He travelled the world between 1810 and 1820, exploring agricultural ideas in Asia, Americas and Mesopotamia. Between 1821-1828 he studied natural sciences in Göttingen, where he eventually became professor. In the early 1830s he moved to Regenwalde (Resko), where he accepted position of the Chairman of the Pomorskie Towarzystwo Ekonomiczne (Pomeranian Economic Society), which he held for the rest of his life. Having his financial needs satisfied, finally he could fulfil his dream and establish Regenwalde Akademie der Landwirtschaft (Academy of Agriculture in Resko), where he taught, studied and lived until his death in 1859.