Central chromatolysis

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Micrograph of the anterior horn of the spinal cord showing motor neurons with central chromatolysis. H&E stain.

Central chromatolysis is a histopathologic change seen in the cell body of a neuron, where the chromatin and cell nucleus are pushed to the cell periphery, in response to axonal injury.[1][2] This response is associated with increased protein synthesis to accommodate for axonal sprouting. In addition to traumatic injuries, central chromatolysis may be caused by vitamin deficiency (pellagra[3]).

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  1. ^ Neuropathology - Basic Reactions. University of Vermont. URL: http://www.uvm.edu/~jkessler/NP/neuropbr.htm Archived January 1, 2010, at the Wayback Machine.. Accessed on: 1 January 2011.
  2. ^ Holland GR (1996). "Experimental trigeminal nerve injury". Crit. Rev. Oral Biol. Med. 7 (3): 237–58. PMID 8909880. 
  3. ^ Piercecchi-Marti MD, Pélissier-Alicot AL, Leonetti G, Tervé JP, Cianfarani F, Pellissier JF (December 2004). "Pellagra: a rare disease observed in a victim of mental and physical abuse". Am J Forensic Med Pathol. 25 (4): 342–4. doi:10.1097/01.paf.0000136589.28903.e5. PMID 15577526. 

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