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Pfam clanCL0199
Available protein structures:
Pfam  structures / ECOD  
PDBsumstructure summary

In molecular biology, the cerato-platanin family of proteins includes the phytotoxin cerato-platanin (CP) produced by the Ascomycete Ceratocystis platani. CP homologs are also found in both the Ascomycota and the Basidiomycota branches of Dikarya.[1] This toxin causes the severe plant disease: canker stain. This protein occurs in the cell wall of the fungus and is involved in the host-pathogen interaction and induces both cell necrosis and phytoalexin synthesis which is one of the first plant defense-related events. CP, like other fungal surface proteins, is able to self-assemble in vitro.[2] CP is a 120 amino acid protein, containing 40% hydrophobic residues. It is one of the rare examples of protein in which contains a Hopf link.[3] The link is formed by covalent loops - the pieces of protein backbone closed by two disulphide bonds[4] (formed out of four cysteine residues). The N-terminal region of CP is very similar to cerato-ulmin, a phytotoxic protein produced by the Ophiostoma species belonging to the hydrophobin family, which also self-assembles.[5]


  1. ^ Chen, Hongxin; Kovalchuk, Andriy; Keriö, Susanna; Asiegbu, Fred O. (20 January 2017). "Distribution and bioinformatic analysis of the cerato-platanin protein family in Dikarya". Mycologia. 105 (2013): 1479–1488. doi:10.3852/13-115. PMID 23928425. S2CID 23984426.
  2. ^ Sbrana F, Bongini L, Cappugi G, Fanelli D, Guarino A, Pazzagli L, Scala A, Vassalli M, Zoppi C, Tiribilli B (September 2007). "Atomic force microscopy images suggest aggregation mechanism in cerato-platanin" (PDF). Eur. Biophys. J. 36 (7): 727–32. doi:10.1007/s00249-007-0159-x. PMID 17431609. S2CID 11585837.
  3. ^ Dabrowski-Tumanski, Pawel; Sulkowska, Joanna I. (2017-03-28). "Topological knots and links in proteins". Proceedings of the National Academy of Sciences. 114 (13): 3415–3420. Bibcode:2017PNAS..114.3415D. doi:10.1073/pnas.1615862114. ISSN 0027-8424. PMC 5380043. PMID 28280100.
  4. ^ Pazzagli L, Cappugi G, Manao G, Camici G, Santini A, Scala A (August 1999). "Purification, characterization, and amino acid sequence of cerato-platanin, a new phytotoxic protein from Ceratocystis fimbriata f. sp. platani". J. Biol. Chem. 274 (35): 24959–64. doi:10.1074/jbc.274.35.24959. PMID 10455173.
  5. ^ Carresi L, Pantera B, Zoppi C, Cappugi G, Oliveira AL, Pertinhez TA, Spisni A, Scala A, Pazzagli L (October 2006). "Cerato-platanin, a phytotoxic protein from Ceratocystis fimbriata: expression in Pichia pastoris, purification and characterization". Protein Expr. Purif. 49 (2): 159–67. doi:10.1016/j.pep.2006.07.006. PMID 16931046.
This article incorporates text from the public domain Pfam and InterPro: IPR010829