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Charantoside is any of several related cucurbitane triterpenoid glycosides found in the fruits bitter melon vine (Momordica charantia).[1] They include:

  • charantoside I, (19R,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol 3-O-β-D-glucopyranoside: amorphous solid.
  • charantoside II, (19R,23R)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol 3-O-β-D-allopyranoside: amorphous solid.
  • charantoside III, (23E)-5β,19-Epoxycucurbita-6,23,25-trien-3β-ol 3-O-β-D-glucopyranoside: amorphous solid.
  • charantoside IV, (23E)-5β,19-Epoxycucurbita-6,23,25-trien-3β-ol 3-O-β-D-allopyranoside: colorless needles, melting at 256–260 °C.
  • charantoside V, (23R)-5β,19-Epoxy-23-methoxycucurbita-6,24-dien-3β-ol 3-O-β-D-glucopyranoside: colorless needles, melting at 235–240 °C.
  • charantoside VI, (23S)-5β,19-Epoxy-23-methoxycucurbita-6,24-dien-3β-ol 3-O-β-D-allopyranoside: amorphous solid.
  • charantoside VII, (23E)-3β-Hydroxycucurbita-6,23,25-trien-5β,19-olide 3-O-β-Dglucopyranoside: colorless needles, melting at 258–262 °C
  • charantoside VIII, (23E)-3β-Hydroxy-7β,25-dimethoxycucurbita-5,23-dien-19-al 3-O-β-D-glucopyranoside: amorphous solid.

Charantosides I through VIII can be extracted from the fresh fruit with methanol and ethyl acetate.[1]

See also[edit]


  1. ^ a b Akihisa T, Higo N, Tokuda H, Ukiya M, Akazawa H, Tochigi Y, Kimura Y, Suzuki T, Nishino H, et al. (2007). "Cucurbitane-Type Triterpenoids from the Fruits of Momordica charantia and Their Cancer Chemopreventive Effects". Journal of Natural Products. 70 (8): 1233–1239. doi:10.1021/np068075p. PMID 17685651.