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Claudia Höbartner

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Claudia Höbartner (born in 1977 in Krems an der Donau) is an Austrian-born chemist. She currently teaches as a professor at Julius-Maximilians-Universität Würzburg.

Life and work

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Claudia Höbartner studied Technical Chemistry at Technische Universität Wien. She did her diploma thesis at ETH Zurich, and after that completed her doctoral studies at Leopold-Franzens-Universität Innsbruck. In 2005, she moved to the University of Illinois in Urbana-Champaign/USA as a postdoc with an Erwin Schrödinger Research Fellowship from the Austrian Science Fund. In 2008, she became the head of a research group at the Max Planck Institute for Biophysical Chemistry (today: MPI for Multidisciplinary Science) in Göttingen. In 2014, she became a professor of chemistry at Georg-August-Universität, Göttingen,[1] and in 2017, she succeeded Gerhard Bringmann as Professor of Organic Chemistry I at the Institute of Organic Chemistry, University of Würzburg.[2]

Research areas

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Höbartner's scientific interest is in the nucleic acids DNA and RNA and their function as biocatalysts that mediate the course of biochemical reactions. In 2016, she published the first X-ray structure of a DNA enzyme (deoxyribozyme) that catalyzes the ligation of two RNA fragments in Nature.

She has developed DNA enzymes for the detection of modified nucleotides in RNA, too.[3][4] In 2020, she reported, also in Nature[5] the first methyltransferase ribozyme (MTR1), and published its structure and mechanism in 2022.[6] The discovery of the methyltransferase ribozyme provides clues to the catalytic abilities of RNA, which may have played an important role during early evolution. Methylated nucleotides are found in the RNA of all living organisms at precisely defined sites that are essential for the structure and function of RNA. In addition, methylated nucleotides play an important role in mRNA vaccines.

Another project of her research group deals with the investigation of the replication inhibition of the corona virus by Remdesivir and Molnupiravir[7]

Academic distinctions

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  • 2004 Roche Symposium Award (Leading chemists of the next decade), Basel, Switzerland
  • 2005 Georg and Christine Sosnovsky Award, (Thesis Award, Universität Innsbruck, Austria)
  • 2005 Erwin Schrödinger Postdoctoral Fellowship, FWF
  • 2007 Hertha Firnberg fellowship, Austrian Science Fund (FWF) & BMWF
  • 2010 European Young Chemist Award (EuCheMS, Silver Medal)[8]
  • 2011 Research Award of the Peter and Traudl Engelhorn Foundation
  • 2013 Hellmut Bredereck Foundation Award
  • 2016 ERC Consolidator Grant
  • Since 2019 Corresponding Member Abroad, Austrian Academy of Sciences (ÖAW)
  • 2020 ASEM-DUO-India Fellowship program for Professors
  • 2022 Elected Member, Section Biochemie und Biophysik, German National Academy of Sciences – Leopoldina
  • 2023 Gottfried Wilhelm Leibniz Prize (DFG)[9]
  • 2023 Order of the Bavarian Constitution, Munich, Germany[10]
  • 2023: Familie-Hansen-Award

Other activities

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Selected publications

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  • C. Höbartner, M.-O. Ebert, B. Jaun, R. Micura: RNA‐Konformationsgleichgewichte und der Einfluss der Methylierung von Nucleobasen auf die Gleichgewichtslage. In: Wiley Online Library. 2002. doi:10.1002/1521-3757(20020215)114:4<619::AID-ANGE619>3.0.CO;2-2
  • A. Serganov, S. Keiper, L. Malinina, C. Höbartner u. a.: Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. In: Nat Struct Mol Biol. Band 12, 2005, S. 218–224. doi:10.1038/nsmb906
  • D. Heller, H. Jin, B. Martinez, C. Höbartner u. a.: Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes. In: Nature Nanotech. Band 4, 2009, S. 114–120. doi:10.1038/nnano.2008.369
  • A. Ponce-Salvatierra, K. Wawrzyniak-Turek, U. Steuerwald, C. Höbartner u. a.: Crystal structure of a DNA catalyst. In: Nature. Band 529, 2016, S. 231–234. doi:10.1038/nature16471
  • C. P. M. Scheitl, M. Ghaem Maghami, A. K. Lenz, C. Höbartner u. a.: Site-specific RNA methylation by a methyltransferase ribozyme. In: Nature. Band 587, 2020, S. 663–667. doi:10.1038/s41586-020-2854-z
  • A. Liaqat, C. Stiller, M. Michel, M. V. Sednev, C. Höbartner: N6-isopentenyladenosine in RNA determines the cleavage site of endonuclease deoxyribozymes. In: Angew. Chem. Int. Ed. Band 59, 2020, S. 18627–18631. doi:10.1002/anie.202006218
  • List of publications

References

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  1. ^ "Appointments, retirements, emeritus appointments, habilitations and rehabilitations". Georg-August Universität Göttingen (in German). 2014-06-30. Retrieved 2024-03-07.
  2. ^ "Prof. Dr. C. Höbartner - THE HÖBARTNER GROUP: ORGANIC AND BIOMOLECULAR CHEMISTRY". www.chemie.uni-wuerzburg.de. Retrieved 2024-03-07.
  3. ^ Liaqat, Anam; Sednev, Maksim V.; Stiller, Carina; Höbartner, Claudia (2021-08-23). "RNA-Cleaving Deoxyribozymes Differentiate Methylated Cytidine Isomers in RNA". Angewandte Chemie International Edition. 60 (35): 19058–19062. doi:10.1002/anie.202106517. ISSN 1433-7851. PMC 8457104. PMID 34185947.
  4. ^ Sednev, Maksim V.; Liaqat, Anam; Höbartner, Claudia (2022-02-09). "High-Throughput Activity Profiling of RNA-Cleaving DNA Catalysts by Deoxyribozyme Sequencing (DZ-seq)". Journal of the American Chemical Society. 144 (5): 2090–2094. doi:10.1021/jacs.1c12489. ISSN 0002-7863. PMID 35081311. S2CID 246297331.
  5. ^ Scheitl, Carolin P. M.; Ghaem Maghami, Mohammad; Lenz, Ann-Kathrin; Höbartner, Claudia (2020-11-26). "Site-specific RNA methylation by a methyltransferase ribozyme". Nature. 587 (7835): 663–667. doi:10.1038/s41586-020-2854-z. ISSN 0028-0836. PMC 7116789. PMID 33116304.
  6. ^ Scheitl, Carolin P. M.; Mieczkowski, Mateusz; Schindelin, Hermann; Höbartner, Claudia (2022-03-17). "Structure and mechanism of the methyltransferase ribozyme MTR1". Nature Chemical Biology. 18 (5): 547–555. doi:10.1038/s41589-022-00976-x. ISSN 1552-4450. PMC 7612680. PMID 35301481.
  7. ^ Kabinger, Florian; Stiller, Carina; Schmitzová, Jana; Dienemann, Christian; Kokic, Goran; Hillen, Hauke S.; Höbartner, Claudia; Cramer, Patrick (2021-09-13). "Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis". Nature Structural & Molecular Biology. 28 (9): 740–746. doi:10.1038/s41594-021-00651-0. ISSN 1545-9993. PMC 8437801. PMID 34381216.
  8. ^ "EuChemS Young Chemists' Award". EuChemS. Retrieved 2024-03-07.
  9. ^ "Prof. Dr. Claudia Höbartner - Gottfried Wilhelm Leibniz Prizewinner 2023". www.dfg.de. Retrieved 2024-03-07.
  10. ^ "Ordensträger Bayerischer Verdienstorden - 2023" (PDF). www.bayern.de. Retrieved 2024-03-07.
  11. ^ "RSC Chemical Biology". Royal Society of Chemistry. Retrieved 2024-03-07.
  12. ^ "ChemBioChem: Editorial Advisory Board". European Chemical Societies Publishing. 2024-03-07. Retrieved 2024-03-07.
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