Cloacal exstrophy

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Cloacal exstrophy
Synonyms Omphalocele-cloacal exstrophy-imperforate anus-spinal defect syndrome
Classification and external resources
Specialty medical genetics
ICD-10 Q64.1
OMIM 258040
Orphanet 93929

Cloacal exstrophy (EC) is a severe birth defect wherein much of the abdominal organs (the bladder and intestines) are exposed. It often causes the splitting of both male and female genitalia (specifically, the penis and clitoris respectively), and the anus is occasionally sealed.[citation needed]

Cloacal exstrophy is a rare birth defect, present in 1/200,000 pregnancies and 1/400,000 live births.[citation needed]

It is caused by a defect of the ventral body wall—mesodermal migration is inhibited and folding fails.[citation needed]

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