CobB
| NAD-dependent deacetylase | |||||||
|---|---|---|---|---|---|---|---|
 Crystallographic structure of the CobB protein (rainbow colored, N-terminus = blue, C-terminus = red) complexed with a portion of histone H4 (magenta) where the sidechain of acylated lysine-16 is displayed as stick diagram.[1] | |||||||
| Identifiers | |||||||
| Symbol | npdA | ||||||
| Alt. symbols | cobB, ycfY | ||||||
| NCBI gene | 945687 | ||||||
| PDB | 1S5P | ||||||
| UniProt | P75960 | ||||||
| |||||||
CobB is a bacterial protein that belongs to the sirtuin family, a broadly conserved family of NAD+-dependent protein deacetylases.[2][3]
References
- ^ PDB: 1S5P; Zhao K, Chai X, Marmorstein R (March 2004). "Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli". J. Mol. Biol. 337 (3): 731–41. doi:10.1016/j.jmb.2004.01.060. PMID 15019790.
- ^ Starai VJ, Celic I, Cole RN, Boeke JD, Escalante-Semerena JC (December 2002). "Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine". Science. 298 (5602): 2390–2. doi:10.1126/science.1077650. PMID 12493915.
- ^ Schwer B, Verdin E (February 2008). "Conserved metabolic regulatory functions of sirtuins". Cell Metab. 7 (2): 104–12. doi:10.1016/j.cmet.2007.11.006. PMID 18249170.
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