Cohesin domain

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PDB 1aoh EBI.jpg
single cohesin domain from the scaffolding protein cipa of the clostridium thermocellum cellulosome
Symbol Cohesin
Pfam PF00963
Pfam clan CL0203
InterPro IPR002102
SCOP 1anu
CDD cd08546

In molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.[1]

The scaffoldin component of the cellulolytic bacterium Clostridium thermocellum is a non-hydrolytic protein which organises the hydrolytic enzymes into a large complex, called the cellulosome. Scaffoldin comprises a series of functional domains, amongst which is a single cellulose-binding domain and nine cohesin domains which are responsible for integrating the individual enzymatic subunits into the complex.


  1. ^ Shimon LJ, Bayer EA, Morag E, Lamed R, Yaron S, Shoham Y, Frolow F (March 1997). "A cohesin domain from Clostridium thermocellum: the crystal structure provides new insights into cellulosome assembly". Structure. 5 (3): 381–90. doi:10.1016/s0969-2126(97)00195-0. PMID 9083107. 

This article incorporates text from the public domain Pfam and InterPro IPR002102