Fosbretabulin

Fosbretabulin
Clinical data
Other names	CA4P; CA4PD; fosbretabulin; fosbretabulin disodium
Identifiers
	IUPAC name Phosphoric acid mono-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester;
PubChem CID	5351387;
ChemSpider	4508406;
CompTox Dashboard (EPA)	DTXSID401028843 ;
Chemical and physical data
Formula	C18H21O8P
Molar mass	396.32 g/mol (exact mass : 396.097404) g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=P(O)(O)Oc1c(OC)ccc(c1)\C=C/c2cc(OC)c(OC)c(OC)c2;
	InChI InChI=1S/C18H21O8P/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3/h5-11H,1-4H3,(H2,19,20,21)/b6-5-; Key:WDOGQTQEKVLZIJ-WAYWQWQTSA-N;
	(verify)

For more information about this drug and its actions, see combretastatin.

Combretastatin A-4 phosphate (phosbretabulin, and its salt phosbretabulin disodium) is a microtubule destabilising drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumours causing central necrosis. It is a derivative of combretastatin.

Combretastatin A-4 phosphate (CA4P) is a prodrug. In vivo, it is dephosphorylated to its active metabolite, combretastatin A-4.^[1]

CA4P is also known as Fosbretabulin Tromethamine.^[2]

In July 2007 the pharmaceutical company OXiGENE initiated a 180-patient phase III clinical trial of CA-4-P in combination with carboplatin for the treatment of anaplastic thyroid cancer.^[3] There is currently no fully FDA approved treatment for this form of cancer.

By 2017 it had completed multiple clinical trials (e.g. for solid tumours,^[4] non-small cell lung cancer^[5]) with more in progress.^[6]

References

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

[1] Combretastatin A-4 phosphate on www.cancer.gov

[2] A Ph 2 Study of Fosbretabulin in Subjects w Pancreatic or Gastrointestinal Neuroendocrine Tumors w Elevated Biomarkers (GI-NETorPNET)

[3] Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid Cancer

[4] Safety and Effectiveness of Combretastatin A-4 Phosphate Combined With Chemotherapy in Advanced Solid Tumors

[5] A Safety and Efficacy Study of Carboplatin, Paclitaxel, Bevacizumab and CA4P in Non-Small Cell Lung Cancer (FALCON)

[6] CA4P clinical trials

[1]

[2]

[3]

[4]

[5]

[6]

See also

References