Condensation domain

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PDB 1l5a EBI.jpg
crystal structure of vibh, an nrps condensation enzyme
Symbol Condensation
Pfam PF00668
Pfam clan CL0149
InterPro IPR001242
SCOP 1l5a

In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.[1]


  1. ^ Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA (August 1998). "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. PMID 9712910. doi:10.1074/jbc.273.35.22773. 

This article incorporates text from the public domain Pfam and InterPro IPR001242