Condensation domain

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Condensation
PDB 1l5a EBI.jpg
crystal structure of vibh, an nrps condensation enzyme
Identifiers
Symbol Condensation
Pfam PF00668
Pfam clan CL0149
InterPro IPR001242
SCOP 1l5a
SUPERFAMILY 1l5a

In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.[1]

References[edit]

  1. ^ Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA (August 1998). "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. PMID 9712910. doi:10.1074/jbc.273.35.22773. 

This article incorporates text from the public domain Pfam and InterPro IPR001242