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Conjugated linoleic acid

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Conjugated linoleic acids (CLA) are a family of at least 28[1] isomers of linoleic acid found mostly in the meat and dairy products derived from ruminants. CLAs can be either cis- or trans-fats and the double bonds of CLAs are conjugated and separated by a single bond between them.

CLA is marketed as a dietary supplement on the basis of its supposed health benefits.[2]

History

The biological activity of CLA was noted by researchers in 1979 who found it to inhibit chemically induced cancer in mice[3] and research on its biological activity has continued.[4]

In 2008, the United States Food and Drug Administration categorized CLA as generally recognized as safe (GRAS).[5]

Biochemistry

Most studies of CLAs have used a mixture of isomers wherein the isomers c9,t11-CLA (rumenic acid) and t10,c12-CLA were the most abundant.[6] More recent studies using individual isomers indicate that the two isomers have very different health effects.[7][8]

Conjugated linoleic acid is both a trans fatty acid and a cis fatty acid. The cis bond causes a lower melting point and ostensibly also the observed beneficial health effects. Unlike other trans fatty acids, it may have beneficial effects on human health.[9] CLA is conjugated, and in the United States, trans linkages in a conjugated system are not counted as trans fats for the purposes of nutritional regulations and labeling.[citation needed] CLA and some trans isomers of oleic acid are produced by microorganisms in the rumens of ruminants. Non-ruminants, including humans, produce certain isomers of CLA from trans isomers of oleic acid, such as vaccenic acid, which is converted to CLA by delta-9-desaturase.[10][11]

In healthy humans, CLA and the related conjugated linolenic acid (CLNA) isomers are bioconverted from linoleic acid and alpha-linolenic acid, respectively, mainly by Bifidobacterium bacteria strains inhabiting the gastrointestinal tract.[12] However, this bioconversion may not occur at any significant level in those with a digestive disease, gluten sensitivity, and/or dysbiosis.[13][14][15][16]

Health

CLA is marketed in dietary supplement form for its supposed anti-cancer benefit (for which there is some evidence, but no known mechanism, and very few studies done so far[17]) and as a bodybuilding aid.[2] A 2004 review of the evidence said that while CLA seemed to benefit non-human animals, there was a lack of good evidence of human health benefits, despite the many claims made for it.[18]

Likewise, there is insufficient evidence that CLA has a useful benefit for overweight or obese people as it has no long-term effect on body composition.[19] CLA has shown an effect on insulin response in diabetic rats but there is no evidence of this effect in humans.[20]

Dietary sources

Food products from grass-fed ruminants (e.g. mutton and beef) are good sources of CLA, and contain much more of it than those from grain-fed animals.[21] Meat and dairy products from grass-fed animals can produce 300-500% more CLA than those of cattle fed the usual diet of 50% hay and silage, and 50% grain.[22] Eggs from chickens that have been fed CLA are also rich in CLA, and CLA in eggs has been shown to survive the temperatures encountered during frying.[23] Some mushrooms, such as Agaricus bisporus and Agaricus subrufescens, are rare non-animal sources of CLA.[24][25]

See also

References

Template:Research help

  1. ^ Banni S (June 2002). "Conjugated linoleic acid metabolism". Current Opinion in Lipidology. 13 (3): 261–6. doi:10.1097/00041433-200206000-00005. PMID 12045395.
  2. ^ a b Talbott SM, Hughes K (2007). "Conjugated linoleic acid". The Health Professional's Guide to Dietary Supplements. Lippincott Williams & Wilkins. pp. 14–. ISBN 978-0-7817-4672-4. {{cite book}}: |work= ignored (help)
  3. ^ Ha YL, Grimm NK, Pariza MW; Grimm; Pariza (1987). "Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid". Carcinogenesis. 8 (12): 1881–7. doi:10.1093/carcin/8.12.1881. PMID 3119246.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Pariza MW (June 2004). "Perspective on the safety and effectiveness of conjugated linoleic acid". Am. J. Clin. Nutr. 79 (6 Suppl): 1132S–1136S. PMID 15159246.
  5. ^ "CLA approved as food ingredient". University of Wisconsin Madison. July 25, 2008. On July 24, the U.S. Food and Drug Administration announced its finding that conjugated linoleic acid, known as CLA, is "generally regarded as safe" for use in foods
  6. ^ "Fatty Acid Profiles of Liver, Adipose Tissue, Speen, and Heart of Mice Fed Diets Containing T10, C-12-, and C9, T11-Conjugated Linoleic Adic".
  7. ^ Tricon S; Burdge GC; Kew S; et al. (September 2004). "Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in most healthy humans". Am. J. Clin. Nutr. 80 (3): 614–20. PMID 15321800. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  8. ^ Ulf Risérus, MMed; Samar Basu; Stefan Jovinge, MD; Gunilla Nordin Fredrikson; Johan Ärnlöv, MD; Bengt Vessby, MD (September 2002). "Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein". American Heart Association Journals. 106 (15): 1925–9. doi:10.1161/01.CIR.0000033589.15413.48. PMID 12370214. 01.CIR.0000033589.15413.48v1. Retrieved 2007-02-19.
  9. ^ II International Congress on CLA from Experimental Models to Human Application
  10. ^ Kuhnt K, Kraft J, Moeckel P, Jahreis G; Kraft; Moeckel; Jahreis (April 2006). "Trans-11-18 : 1 is effectively Delta9-desaturated compared with trans-12-18 : 1 in humans". Br J Nutr. 95 (4): 752–761. doi:10.1079/BJN20051680. PMID 16571155.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ Banni S, Angioni E, Murru E, Carta G, Melis M, Bauman D, Dong Y, Ip C; Angioni; Murru; Carta; Melis; Bauman; Dong; Ip (2001). "Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland". Nutr Cancer. 41 (1–2): 91–7. doi:10.1080/01635581.2001.9680617. PMID 12094634.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  12. ^ Carina Paola Van Nieuwenhove; Victoria Terán; Silvia Nelina González. "Chapter 3: Conjugated Linoleic and Linolenic Acid Production by Bacteria: Development of Functional Foods". In Everlon Cid Rigobelo (ed.). Probiotics. doi:10.5772/50321. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)
  13. ^ Estelle Devillard; Freda M. McIntosh; Sylvia H. Duncan; R. John Wallace (March 2007). "Metabolism of Linoleic Acid by Human Gut Bacteria: Different Routes for Biosynthesis of Conjugated Linoleic Acid". Journal of Bacterioly. 189 (6): 2566–2570. doi:10.1128/JB.01359-06.
  14. ^ E. Barrett, R. P. Ross, G. F. Fitzgerald, and C. Stanton1 (April 2007). "Rapid Screening Method for Analyzing the Conjugated Linoleic Acid Production Capabilities of Bacterial Cultures". Applied and Environmental Microbiology. 73 (7): 2333–2337. doi:10.1128/AEM.01855-06. PMC 1855641. PMID 17277221.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
  15. ^ Gorissen L, De Vuyst L, Raes K, De Smet S, Leroy F.; De Vuyst; Raes; De Smet; Leroy (April 2012). "Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains". International Journal of Food Microbiology. 155 (3): 234–240. doi:10.1016/j.ijfoodmicro.2012.02.012. PMID 22405353.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  16. ^ Esther Jiméneza; M. Antonia Villar-Tajadurab; María Marína; Javier Fontechab; Teresa Requenac; Rebeca Arroyoa; Leónides Fernándeza; Juan M. Rodrígueza (July 2012). "Complete Genome Sequence of Bifidobacterium breve CECT 7263, a Strain Isolated from Human Milk". Journal of Bacterioly. 194 (14): 3762–3763. doi:10.1128/JB.00691-12. PMC 3393482. PMID 22740680.
  17. ^ Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD, Wahle KW (2004). "Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers". Carcinogenesis. 25 (7): 1185–91. doi:10.1093/carcin/bgh116. PMID 14976130.
  18. ^ Rainer L, Heiss CJ; Heiss (June 2004). "Conjugated linoleic acid: health implications and effects on body composition". J Am Diet Assoc (Review). 104 (6): 963–. doi:10.1016/j.jada.2004.03.016. PMID 15175596.
  19. ^ Onakpoya IJ, Posadzki PP, Watson LK, Davies LA, Ernst E; Posadzki; Watson; Davies; Ernst (March 2012). "The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials". Eur J Nutr (Systematic review). 51 (2): 127–34. doi:10.1007/s00394-011-0253-9. PMID 21990002.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  20. ^ Davì G, Santilli F, Patrono C; Santilli; Patrono (August 2010). "Nutraceuticals in diabetes and metabolic syndrome". Cardiovasc Ther (Review). 28 (4): 216–26. doi:10.1111/j.1755-5922.2010.00179.x. PMID 20633024.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  21. ^ T. R. Dhiman; L. D. Satter; M. W. Pariza; M. P. Galli; K. Albright; M. X. Tolosa (1 May 2000). "Conjugated Linoleic Acid (CLA) Content of Milk from Cows Offered Diets Rich in Linoleic and Linolenic Acid". Journal of Dairy Science. 83 (5): 1016–1027. doi:10.3168/jds.S0022-0302(00)74966-6. PMID 10821577. Retrieved 2006-05-27.
  22. ^ T. R. Dhiman (2001). "Role of diet on conjugated linoleic acid content of milk and meat" (PDF). Journal of Animal Science. 79. Retrieved 2007-03-09.
  23. ^ Lin Yang, Ying Cao, Zhen-Yu Chen; Cao; Chen (2004). "Stability of conjugated linoleic acid isomers in egg yolk lipids during frying". Food Chemistry. 86 (4). Elsevier: 531–535. doi:10.1016/j.foodchem.2003.09.006.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  24. ^ Chen, S.; Oh, SR; Phung, S; Hur, G; Ye, JJ; Kwok, SL; Shrode, GE; Belury, M; Adams, LS (2006). "Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus)". Cancer Res. 66 (24): 12026–12034. doi:10.1158/0008-5472.CAN-06-2206. PMID 17178902. {{cite journal}}: Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)
  25. ^ W. J. Jang S. W. Hyung. "Production of natural c9,t11 conjugated linoleic acid (c9,t11 CLA) by submerged liquid culture of mushrooms". Division of Applied Life Science (BK21), Graduate School, Gyeongsang National University, Jinju, 660-701, South Korea. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: location (link)
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