Coronavirus 3′ UTR pseudoknot

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Coronavirus 3′ UTR pseudoknot
Predicted secondary structure and sequence conservation of Corona_pk3
Other data
RNA typeCis-reg
PDB structuresPDBe

The Coronavirus 3′ UTR pseudoknot is an RNA structure found in the coronavirus genome. Coronaviruses contain 30 kb single-stranded positive-sense RNA genomes. The 3′ UTR region of these coronavirus genomes contains a conserved ~55 nucleotide pseudoknot structure which is necessary for viral genome replication.[1] The mechanism of cis-regulation is unclear, but this element is postulated to function in the plus-strand.

Other RNA families identified in the coronavirus include the coronavirus SL-III cis-acting replication element (CRE), the coronavirus frameshifting stimulation element, the coronavirus 3′ stem-loop II-like motif (s2m) and the coronavirus packaging signal.


  1. ^ Williams GD, Chang RY, Brian DA (October 1999). "A phylogenetically conserved hairpin-type 3′ untranslated region pseudoknot functions in coronavirus RNA replication". Journal of Virology. 73 (10): 8349–8355. doi:10.1128/JVI.73.10.8349-8355.1999. PMC 112852. PMID 10482585.

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