Corticotropin-releasing hormone binding protein family
| Corticotropin-releasing factor binding protein (CRF-BP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CRF-BP | ||||||||
| Pfam | PF05428 | ||||||||
| InterPro | IPR008435 | ||||||||
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Corticotropin-releasing factor binding protein family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP).
Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development.
Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.[1]
Human proteins
References
- ^ Seasholtz AF, Valverde RA, Denver RJ (2002). "Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals". J. Endocrinol. 175 (1): 89–97. doi:10.1677/joe.0.1750089. PMID 12379493.