CRHBP

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CRHBP
Identifiers
AliasesCRHBP, CRF-BP, CRFBP, corticotropin releasing hormone binding protein
External IDsOMIM: 122559 MGI: 88497 HomoloGene: 1418 GeneCards: CRHBP
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CRHBP
Genomic location for CRHBP
Band5q13.3Start76,953,045 bp[1]
End76,981,158 bp[1]
RNA expression pattern
PBB GE CRHBP 205984 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001882

NM_198408

RefSeq (protein)

NP_001873

NP_940800

Location (UCSC)Chr 5: 76.95 – 76.98 MbChr 13: 95.43 – 95.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Corticotropin-releasing factor-binding protein is a protein that in humans is encoded by the CRHBP gene.[5][6] It belongs to corticotropin-releasing hormone binding protein family.

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145708 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021680 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW (Jun 1993). "Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)" (PDF). Genomics. 16 (1): 63–8. doi:10.1006/geno.1993.1141. PMID 8198617.
  6. ^ a b "Entrez Gene: CRHBP corticotropin releasing hormone binding protein".

External links[edit]

Further reading[edit]