Cryogenine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article is about the alkaloid from the plants in the genus Heimia. For the antipyretic drug, see Phenicarbazide.
Cryogenine
Cryogenine.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C26H29NO5
Molar mass 435.512 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Cryogenine, also known as vertine or (10α)-4,5-dimethoxy-2-hydroxylythran-12-one, is a biphenylquinolizidine lactone alkaloid from the plants Sinicuichi (Heimia salicifolia) and H. myrtifolia. The compound has no psychoactive properties in humans up to 310 mg, but has shown anti-inflammatory activity similar to aspirin.[1]

The freebase form melts at 250–251 °C and is soluble in moderately polar organic solvents such as chloroform, methylene chloride, benzene, and methanol, but is insoluble in water and petroleum ether.

In the development of thin layer chromatography plates with diazotized p-nitroaniline spray, cryogenine produces a purple spot (as does sinicuichine, another biphenylquinolizidine lactone alkaloid found in Heimia species).

See also[edit]

References[edit]

  1. ^ M. H. Malone, A. Rother (1994). "Heimia salicifolia: A phytochemical and phytopharmacologic review". J. Ethnopharmacol. 42 (3): 135–159. doi:10.1016/0378-8741(94)90080-9. PMID 7934084.