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Cumulina (October 3, 1997-May 5, 2000), a mouse, was the first animal cloned from adult cells that survived to adulthood. She was cloned using the Honolulu technique developed by the Ryuzo Yanagimachi research group, 'Team Yana', at the former campus of the John A. Burns School of Medicine located at the University of Hawai'i at Mānoa. She was a brown Mus musculus or common house mouse. Cumulina was named after the cumulus cells surrounding the developing oocyte in the ovarian follicle in mice. Nuclei from these cells were put into egg cell devoid of their original nuclei in the Honolulu cloning technique. All other mice produced by the Yanagimachi lab are just known by a number.[1]

Cumulina was able to produce two healthy litters. She was retired after the second.

Cumulina's preserved remains can be visited at the Institute for Biogenesis Research, a part of the John A. Burns School of Medicine laboratory, in Honolulu, Hawaii.

Some of her descendants have been displayed at the Bishop Museum and the Museum of Science and Industry in Chicago, Illinois.[2]


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