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Cuore, pronounced [ˈkwɔːre], is the Italian-language word for "heart".

Cuore or CUORE may also refer to:

  • CUORE Experiment, a particle physics facility in the Laboratori Nazionali del Gran Sasso in Italy
  • Daihatsu Cuore, a vehicle built by the Japanese car maker Daihatsu
  • Heart (1948 film), an Italian drama film directed by Vittorio De Sica and Duilio Coletti
  • Heart (novel), an 1886 children's novel by Edmondo De Amicis