D-161

D-161
Identifiers
	IUPAC name 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol;
PubChem CID	11545250;
ChemSpider	9720029;
Chemical and physical data
Formula	C25H27NO2
Molar mass	373.486 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc2ccc(cc2)CNC(CC3)COC3C(c1ccccc1)c4ccccc4;
	InChI InChI=1S/C25H27NO2/c27-23-14-11-19(12-15-23)17-26-22-13-16-24(28-18-22)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-12,14-15,22,24-27H,13,16-18H2/t22-,24-/m0/s1; Key:CFCFEXCFOQWYQK-UPVQGACJSA-N;
	(verify)

D-161^[1] is a chemical known in research circles as a triple reuptake inhibitor. Although this compound has lent support to the inclusion of dopamine in the monoamine hypothesis of depression, D-161 has not been tested in clinical trials.

References

^ Dutta, A.; Ghosh, B.; Biswas, S.; Reith, M. (2008). "D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action". European Journal of Pharmacology. 589 (1–3): 73–79. doi:10.1016/j.ejphar.2008.05.008. PMID 18561912.

[1] Dutta, A.; Ghosh, B.; Biswas, S.; Reith, M. (2008). "D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action". European Journal of Pharmacology. 589 (1–3): 73–79. doi:10.1016/j.ejphar.2008.05.008. PMID 18561912.

[1]