DEFA5

DEFA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZMP, 2LXZ, 2MIT, 3I5W, 4E82, 4E83, 4E86, 4RBW, 4RBX, 5CUM, 5CUJ, 5CUI
Identifiers
Aliases	DEFA5, DEF5, HD-5, defensin alpha 5, alpha defensin 5
External IDs	OMIM: 600472 MGI: 3711900 HomoloGene: 128604 GeneCards: DEFA5
Gene location (Human)
Chr.	Chromosome 8 (human)
End	7,056,739 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	21,556,012 bp
RNA expression pattern
	Top expressed in
	duodenum; ; appendix; ; gastric mucosa; ; right lung; ; transverse colon; ; lymph node; ; rectum; ; blood; ; body of pancreas; ; body of stomach;
	Top expressed in
	ileum; ; jejunum; ; duodenum; ; colon; ; pancreas; ; thymus; ; esophagus; ; liver; ; stomach; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity;
Cellular component	Golgi lumen; secretory granule lumen; transport vesicle; cytoplasmic vesicle; extracellular region; extracellular space;
Biological process	defense response; defense response to bacterium; defense response to fungus; antimicrobial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response; positive regulation of membrane permeability; killing of cells of other organism; innate immune response in mucosa; antibacterial humoral response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; membrane disruption in other organism; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	1670
	100041688
	ENSG00000164816; ENSG00000285251
	ENSMUSG00000061845
	Q01523
	E9QLQ1
	NM_021010
	NM_001177481
	NP_066290
	NP_001170952
	Wikidata
View/Edit Human	View/Edit Mouse

Defensin, alpha 5 (DEFA5) also known as human alpha defensin 5 (HD5) is a human protein that is encoded by the DEFA5 gene.^[5]^[6] DEFA5 is expressed in the Paneth cells of the ileum.^[7]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000285251 GRCh38: Ensembl release 89: ENSG00000164816, ENSG00000285251 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061845 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Jones DE, Bevins CL (January 1993). "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel". FEBS Lett. 315 (2): 187–92. doi:10.1016/0014-5793(93)81160-2. PMID 8417977.
^ Zhao C, Wang I, Lehrer RI (24 Nov 1996). "Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells". FEBS Lett. 396 (2–3): 319–22. doi:10.1016/0014-5793(96)01123-4. PMID 8915011.

References

Further reading