With Martin Greenberg, Kyle founded Gnome Press in 1948. He has written two pictorial histories of science fiction (A Pictorial History of Science Fiction and The Illustrated Book of Science Fiction Ideas and Dreams) and three licensed novels set in the Lensman universe (The Dragon Lensman, Lensman from Rigel and Z-Lensman).
He attended the first Worldcon, and both wrote and printed the "Yellow Pamphlet" condemning the organizers. The manifesto led chairman Sam Moskowitz to ban several prominent members of the Futurians from that convention.
Kyle chaired the 1956 14th World Science Fiction Convention (NyCon II), inspiring the fan catchphrase, "Dave Kyle says you can't sit here." He was created a Knight of The Order of Saint Fantony in 1961, and was awarded the Big Heart Award in 1973. Kyle was also Fan Guest of Honor at ConStellation, the 41st World Science Fiction Convention, in 1983.
Kyle married another fan, Ruth Evelyn Landis (whom he had met through fandom), on August 31, 1957; for their honeymoon they flew to England for the 1957 Worldcon there, together with 53 friends and in-laws, on a specially chartered flight. They remained married until her death on January 5, 2011. They had a son Arthur and a daughter Kerry.
- Kyle, David. "The Great Exclusion Act of 1939". Mimosa no. 6.
- Kyle, Dave. "Caravan to the Stars". Mimosa no. 22, pp. 4–8.
- Kyle, David. "A Fan-Tastic Honeymoon: An Air Wonder Story". Mimosa no. 30, pp. 25–27.
- "Obituaries: Ruth Evelyn Kyle, 81, formerly of Potsdam". NorthCountryNow.com, January 6, 2011.