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MacIsaac established his footing in the ice hockey industry when he won the NCAA championship with the University of Maine in 1992–93. He was also was selected for the Hockey East All-Rookie team that season. During his collegiate career, MacIsaac majored in physical education with a concentration in teaching and coaching.
In 1995, MacIsaac began his professional hockey career in the International Hockey League. He played more than 750 professional games before moving on to the NHL's primary feeder league, the American Hockey League.
After a nearly 14 season playing career, MacIsaac would move on to coaching. He led the Danbury Mad Hatters (EPHL) to a 30-18-2 record as the head coach in 2008–09. In 2009, MacIsaac would become the head coach of the Louisiana IceGators (SPHL). For the 2011–12 season, he would assume the same role for Bjorninn HC of the Icelandic Hockey League and Bjorninn HC won the league championship that season. He would be named head coach of the Icelandic National team where he led the team to a bronze medal at the World Championships.
MacIsaac speaks 5 different languages: English, French, Russian, Icelandic, and Italian.
Awards and accomplishments:
- 1992–93 – NCAA Champion (UMaine) & Hockey East All-Rookie Team Selection
- 1998 – Calder Cup Champion (Philadelphia Phantoms)
- 2001 – AHL Plus/Minus Player of the Year
- 2012 – Icelandic Hockey League Champions & Named Assistant Coach of Icelandic National Team
- 2013 – Head coach of the Icelandic National Hockey Team.
- 1994–95 University of Maine (NCAA)
- 1998–99 Philadelphia Phantoms (AHL)
- 1999–00 Lowell Lock Monsters (AHL)
- 2000–01 Kentucky Thoroughblades (AHL)
- 2001–02 Hartford Wolf Pack (AHL)
- 2002–03 Amur Khabarovsk (Russian Superleague)
- 2005–06 Danbury Thrashers (UHL)